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10.1101/2021.05.04.442548 http://scihub22266oqcxt.onion/10.1101/2021.05.04.442548 33972946!8109209!33972946     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       bioRxiv 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=33972946|t=2021. ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling |pdf=|usr=}}{{33972946}} gab.com Text ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33972946 #FOAvip ORAI1 and STIM1 are the critical mediators of store-operated Ca (2+) entry by acting as the pore subunit and an endoplasmic reticulum-resident signaling molecule, respectively. In addition to Ca (2+) signaling, STIM1 is also involved in regulation of a cytosolic nucleic acid sensing pathway. Using ORAI1 and STIM1 knockout cells, we examined their contribution to the host response to SARS-CoV-2 infection. STIM1 knockout cells showed strong resistance to SARS-CoV-2 infection due to enhanced type I interferon response. On the contrary, ORAI1 knockout cells showed high susceptibility to SARS-CoV-2 infection as judged by increased expression of viral proteins and a high viral load. Mechanistically, ORAI1 knockout cells showed reduced homeostatic cytoplasmic Ca (2+) concentration and severe impairment in tonic interferon signaling. Transcriptome analysis showed downregulation of multiple cellular defense mechanisms, including antiviral signaling pathways in ORAI1 knockout cells, which are likely due to reduced expression of the Ca (2+) -dependent transcription factors of the activator protein 1 (AP-1) family and MEF2C . Our results identify a novel role of ORAI1-mediated Ca (2+) signaling in regulating the baseline type I interferon level, which is a determinant of host resistance to SARS-CoV-2 infection. Twit Text FOAVip ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33972946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33972946 #FOAvip English Wikipedia <ref>{{Cite pmid|33972946}}</ref> ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling #MMPMID33972946 Wu B; Ramaiah A; Garcia G Jr; Gwack Y; Arumugaswami V; Srikanth S bioRxiv 2021[May]; ä (ä): ä PMID33972946show ga ORAI1 and STIM1 are the critical mediators of store-operated Ca (2+) entry by acting as the pore subunit and an endoplasmic reticulum-resident signaling molecule, respectively. In addition to Ca (2+) signaling, STIM1 is also involved in regulation of a cytosolic nucleic acid sensing pathway. Using ORAI1 and STIM1 knockout cells, we examined their contribution to the host response to SARS-CoV-2 infection. STIM1 knockout cells showed strong resistance to SARS-CoV-2 infection due to enhanced type I interferon response. On the contrary, ORAI1 knockout cells showed high susceptibility to SARS-CoV-2 infection as judged by increased expression of viral proteins and a high viral load. Mechanistically, ORAI1 knockout cells showed reduced homeostatic cytoplasmic Ca (2+) concentration and severe impairment in tonic interferon signaling. Transcriptome analysis showed downregulation of multiple cellular defense mechanisms, including antiviral signaling pathways in ORAI1 knockout cells, which are likely due to reduced expression of the Ca (2+) -dependent transcription factors of the activator protein 1 (AP-1) family and MEF2C . Our results identify a novel role of ORAI1-mediated Ca (2+) signaling in regulating the baseline type I interferon level, which is a determinant of host resistance to SARS-CoV-2 infection. äORAI1 establishes resistance to SARS-CoV-2 infection by regulating ton(epmc).pdf DeepDyve Pubget Overpricing