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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2021 ; 12 (1): 2593 Nephropedia Template TP
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Identification and characterization of a SARS-CoV-2 specific CD8(+) T cell response with immunodominant features #MMPMID33972535
Gangaev A; Ketelaars SLC; Isaeva OI; Patiwael S; Dopler A; Hoefakker K; De Biasi S; Gibellini L; Mussini C; Guaraldi G; Girardis M; Ormeno CMPT; Hekking PJM; Lardy NM; Toebes M; Balderas R; Schumacher TN; Ovaa H; Cossarizza A; Kvistborg P
Nat Commun 2021[May]; 12 (1): 2593 PMID33972535show ga
The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urgent need to map the landscape of immunogenic and immunodominant epitopes recognized by CD8(+) T cells. Here, we analyze samples from 31 patients with COVID-19 for CD8(+) T cell recognition of 500 peptide-HLA class I complexes, restricted by 10 common HLA alleles. We identify 18 CD8(+) T cell recognized SARS-CoV-2 epitopes, including an epitope with immunodominant features derived from ORF1ab and restricted by HLA-A*01:01. In-depth characterization of SARS-CoV-2-specific CD8(+) T cell responses of patients with acute critical and severe disease reveals high expression of NKG2A, lack of cytokine production and a gene expression profile inhibiting T cell re-activation and migration while sustaining survival. SARS-CoV-2-specific CD8(+) T cell responses are detectable up to 5 months after recovery from critical and severe disease, and these responses convert from dysfunctional effector to functional memory CD8(+) T cells during convalescence.