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10.4049/jimmunol.2100195

http://scihub22266oqcxt.onion/10.4049/jimmunol.2100195
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33972373!8165008!33972373
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suck abstract from ncbi


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pmid33972373      J+Immunol 2021 ; 206 (11): 2503-2507
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  • Conserved and Novel Mouse CD8 T Cell Epitopes within SARS-CoV-2 Spike Receptor Binding Domain Protein Identified following Subunit Vaccination #MMPMID33972373
  • Davenport BJ; Morrison TE; Kedl RM; Klarquist J
  • J Immunol 2021[Jun]; 206 (11): 2503-2507 PMID33972373show ga
  • The prior existence of human ACE2 protein-expressing mice used to study SARS-CoV and the rapid development of mouse-adapted virus strains have allowed the study of SARS-CoV-2 in mice, even as we are still learning about its natural pathology in humans. With myriad genetically altered strains on the C57BL/6 background and the abundance of immunological reagents available to interrogate its immune responses, the C57BL/6 mice may provide useful insight into the immunology of SARS-CoV-2 infection and vaccination. To conduct more detailed studies on their T cell responses to vaccines and infection, the epitopes eliciting those responses must be characterized in further detail. In this study, we mapped CD8 T cell epitopes within the receptor binding domain of the SARS-CoV-2 spike protein in C57BL/6 mice. Our study identified five major CD8 T cell epitopes in immunized C57BL/6 mice, including one, VVLSFELL, presented by H-2K(b) and common between SARS-CoV and SARS-CoV-2.
  • |Animals[MESH]
  • |CD8-Positive T-Lymphocytes/*immunology[MESH]
  • |COVID-19 Vaccines/*immunology[MESH]
  • |Epitopes, T-Lymphocyte/*immunology[MESH]
  • |Mice[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology[MESH]


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