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10.1016/j.clindermatol.2020.12.018

http://scihub22266oqcxt.onion/10.1016/j.clindermatol.2020.12.018
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33972060!7836423!33972060
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suck abstract from ncbi

pmid33972060      Clin+Dermatol 2021 ; 39 (1): 98-103
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  • Is the BCG vaccine a useful tool against COVID-19? #MMPMID33972060
  • Zhelezova G; Mateeva V; Mateev G
  • Clin Dermatol 2021[Jan]; 39 (1): 98-103 PMID33972060show ga
  • The Bacillus Calmette-Guerin (BCG) vaccine has been used since 1921 initially for protection against tuberculosis. BCG acts through stimulation of cell-mediated adaptive immunity with activation of the Th1 cells and production of interferon gamma. Additionally, it is able to stimulate the immune system in a nonspecific manner, which results in effectiveness of the BCG against non-mycobacterial infections and in some malignant, autoimmune, and inflammatory diseases. Recently, its potential use in the fight against the coronavirus disease 2019 (COVID-19) pandemic has been suggested. This is based upon the concept of BCG-induced trained innate immunity-a memory-like response of the innate immune system that can realize greater protection in case of re-infection. This hypothesis represents a milestone in the potential use of the BCG vaccine in the fight with the novel coronavirus.
  • |*Adjuvants, Immunologic[MESH]
  • |BCG Vaccine/*immunology[MESH]
  • |COVID-19/mortality/*prevention & control[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]


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