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10.1016/j.xcrm.2021.100288 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100288 33969321!8091032!33969321     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (5): 100288 Nephropedia Template TP {{tp|p=33969321|t=2021. Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms |pdf=|usr=}}{{33969321}} gab.com Text Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33969321 #FOAvip Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebrospinal fluid (CSF) and blood from individuals with COVID-19 with neurological symptoms, we find compartmentalized, CNS-specific T cell activation and B cell responses. All affected individuals had CSF anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies whose target epitopes diverged from serum antibodies. In an animal model, we find that intrathecal SARS-CoV-2 antibodies are present only during brain infection and not elicited by pulmonary infection. We produced CSF-derived monoclonal antibodies from an individual with COVID-19 and found that these monoclonal antibodies (mAbs) target antiviral and antineural antigens, including one mAb that reacted to spike protein and neural tissue. CSF immunoglobulin G (IgG) from 5 of 7 patients showed antineural reactivity. This immune survey reveals evidence of a compartmentalized immune response in the CNS of individuals with COVID-19 and suggests a role of autoimmunity in neurologic sequelae of COVID-19. Twit Text FOAVip Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33969321 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33969321 #FOAvip English Wikipedia <ref>{{Cite pmid|33969321}}</ref> Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms #MMPMID33969321 Song E; Bartley CM; Chow RD; Ngo TT; Jiang R; Zamecnik CR; Dandekar R; Loudermilk RP; Dai Y; Liu F; Sunshine S; Liu J; Wu W; Hawes IA; Alvarenga BD; Huynh T; McAlpine L; Rahman NT; Geng B; Chiarella J; Goldman-Israelow B; Vogels CBF; Grubaugh ND; Casanovas-Massana A; Phinney BS; Salemi M; Alexander JR; Gallego JA; Lencz T; Walsh H; Wapniarski AE; Mohanty S; Lucas C; Klein J; Mao T; Oh J; Ring A; Spudich S; Ko AI; Kleinstein SH; Pak J; DeRisi JL; Iwasaki A; Pleasure SJ; Wilson MR; Farhadian SF Cell Rep Med 2021[May]; 2 (5): 100288 PMID33969321show ga Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebrospinal fluid (CSF) and blood from individuals with COVID-19 with neurological symptoms, we find compartmentalized, CNS-specific T cell activation and B cell responses. All affected individuals had CSF anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies whose target epitopes diverged from serum antibodies. In an animal model, we find that intrathecal SARS-CoV-2 antibodies are present only during brain infection and not elicited by pulmonary infection. We produced CSF-derived monoclonal antibodies from an individual with COVID-19 and found that these monoclonal antibodies (mAbs) target antiviral and antineural antigens, including one mAb that reacted to spike protein and neural tissue. CSF immunoglobulin G (IgG) from 5 of 7 patients showed antineural reactivity. This immune survey reveals evidence of a compartmentalized immune response in the CNS of individuals with COVID-19 and suggests a role of autoimmunity in neurologic sequelae of COVID-19. äDivergent and self-reactive immune responses in the CNS of COVID-19 pa(epmc).pdf DeepDyve Pubget Overpricing