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10.1016/j.isci.2021.102489

http://scihub22266oqcxt.onion/10.1016/j.isci.2021.102489
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33969281!8087581!33969281
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suck abstract from ncbi


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pmid33969281      iScience 2021 ; 24 (6): 102489
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  • Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients #MMPMID33969281
  • Dwyer CJ; Cloud CA; Wang C; Heidt P; Chakraborty P; Duke TF; McGue S; Jeffcoat B; Dunne J; Johnson L; Choi S; Nahhas GJ; Gandy AS; Babic N; Nolte FS; Howe P; Ogretmen B; Gangaraju VK; Tomlinson S; Madden B; Bridges T; Flume PA; Wrangle J; Rubinstein MP; Baliga PK; Nadig SN; Mehrotra S
  • iScience 2021[Jun]; 24 (6): 102489 PMID33969281show ga
  • The SARS-CoV-2 viral pandemic has induced a global health crisis, which requires more in-depth investigation into immunological responses to develop effective treatments and vaccines. To understand protective immunity against COVID-19, we screened over 60,000 asymptomatic individuals in the Southeastern United States for IgG antibody positivity against the viral Spike protein, and approximately 3% were positive. Of these 3%, individuals with the highest anti-S or anti-RBD IgG level showed a strong correlation with inhibition of ACE2 binding and cross-reactivity against non-SARS-CoV-2 coronavirus S-proteins. We also analyzed samples from 94 SARS-CoV-2 patients and compared them with those of asymptomatic individuals. SARS-CoV-2 symptomatic patients had decreased antibody responses, ACE2 binding inhibition, and antibody cross-reactivity. Our study shows that healthy individuals can mount robust immune responses against SARS-CoV-2 without symptoms. Furthermore, IgG antibody responses against S and RBD may correlate with high inhibition of ACE2 binding in individuals tested for SARS-CoV-2 infection or post vaccination.
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