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10.20411/pai.v6i1.417

http://scihub22266oqcxt.onion/10.20411/pai.v6i1.417
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suck abstract from ncbi


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pmid33969248      Pathog+Immun 2021 ; 6 (1): 31-54
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  • The Intersection of COVID-19 and Autoimmunity: What is Our Current Understanding? #MMPMID33969248
  • Winchester N; Calabrese C; Calabrese LH
  • Pathog Immun 2021[]; 6 (1): 31-54 PMID33969248show ga
  • Viral infections have historically had a complex relationship with autoimmune diseases. For patients with preexisting autoimmune disorders, often complicated by immunosuppressive therapies, there are numerous potential effects of COVID-19, a disease of complex immunobiology, including the potential for an altered natural history of COVID-19 when infected. In addition, individuals without recognized autoimmune disease may be vulnerable to virally induced autoimmunity in the forms of autoantibody formation, as well as the development of clinical immune-mediated inflammatory diseases. Until quite recently in the pandemic, this relationship between COVID-19 and autoimmune diseases has been relatively underexplored; yet such investigation offers potential insights into immunopathogenesis as well as for the development of new immune-based therapeutics. Our review examines this relationship through exploration of a series of questions with relevance to both immunopathogenic mechanisms as well as some clinical implications.
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