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10.3389/fimmu.2021.617042

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.617042
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suck abstract from ncbi


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pmid33968019      Front+Immunol 2021 ; 12 (ä): 617042
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  • Investigation of Extracellular Vesicles From SARS-CoV-2 Infected Specimens: A Safety Perspective #MMPMID33968019
  • Nunez Lopez YO; Casu A; Pratley RE
  • Front Immunol 2021[]; 12 (ä): 617042 PMID33968019show ga
  • The coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-2 virus, is wreaking havoc around the world. Considering that extracellular vesicles (EVs) released from SARS-CoV-2 infected cells might play a role in a viremic phase contributing to disease progression and that standard methods for EV isolation have been reported to co-isolate viral particles, we would like to recommend the use of heightened laboratory safety measures during the isolation of EVs derived from SARS-CoV-2 infected tissue and blood from COVID-19 patients. Research needs to be conducted to better understand the role of EVs in SARS-CoV-2 infectivity, disease progression, and transmission. EV isolation procedures should include approaches for protection from SARS-CoV-2 contamination. We recommend the EV and virology scientific communities develop collaborative projects where relationships between endogenous EVs and potentially lethal enveloped viruses are addressed to better understand the risks and pathobiology involved.
  • |COVID-19/*pathology/*transmission[MESH]
  • |Containment of Biohazards/*methods[MESH]
  • |Endocytosis/physiology[MESH]
  • |Extracellular Vesicles/*virology[MESH]
  • |Humans[MESH]
  • |RNA, Viral/blood/genetics[MESH]
  • |SARS-CoV-2[MESH]
  • |Viral Genome Packaging[MESH]


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