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10.1155/2021/9979032 http://scihub22266oqcxt.onion/10.1155/2021/9979032 33967626!8081638!33967626     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2021 ; 2021 (ä): 9979032 Nephropedia Template TP {{tp|p=33967626|t=2021. Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus Infection |pdf=|usr=}}{{33967626}} gab.com Text Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus Infection JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=33967626 #FOAvip Coronaviruses (CoVs) are enveloped and harbor an unusually large (30-32 kb) positive-strand linear RNA genome. Highly pathogenic coronaviruses cause severe acute respiratory syndrome (SARS) (SARS-CoV and SARS-CoV-2) and Middle East respiratory syndrome (MERS) (MERS-CoV) in humans. The coronavirus mouse hepatitis virus (MHV) infects mice and serves as an ideal model of viral pathogenesis, mainly because experiments can be conducted using animal-biosafety level-2 (A-BSL2) containment. Human thymosin beta-4 (Tbeta4), a 43-residue peptide with an acetylated N-terminus, is widely expressed in human tissues. Tbeta4 regulates actin polymerization and functions as an anti-inflammatory molecule and an antioxidant as well as a promoter of wound healing and angiogenesis. These activities led us to test whether Tbeta4 serves to treat coronavirus infections of humans. To test this possibility, here, we established a BALB/c mouse model of coronavirus infection using mouse CoV MHV-A59 to evaluate the potential protective effect of recombinant human Tbeta4 (rhTbeta4). Such a system can be employed under A-BSL2 containment instead of A-BSL3 that is required to study coronaviruses infectious for humans. We found that rhTbeta4 significantly increased the survival rate of mice infected with MHV-A59 through inhibiting virus replication, balancing the host's immune response, alleviating pathological damage, and promoting repair of the liver. These results will serve as the basis for further application of rhTbeta4 to the treatment of human CoV diseases such as COVID-19. Twit Text FOAVip Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus Infection ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=33967626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33967626 #FOAvip English Wikipedia <ref>{{Cite pmid|33967626}}</ref> Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus Infection #MMPMID33967626 Yu R; Mao Y; Li K; Zhai Y; Zhang Y; Liu S; Gao Y; Chen Z; Liu Y; Fang T; Zhao M; Li R; Xu J; Chen W Mediators Inflamm 2021[]; 2021 (ä): 9979032 PMID33967626show ga Coronaviruses (CoVs) are enveloped and harbor an unusually large (30-32 kb) positive-strand linear RNA genome. Highly pathogenic coronaviruses cause severe acute respiratory syndrome (SARS) (SARS-CoV and SARS-CoV-2) and Middle East respiratory syndrome (MERS) (MERS-CoV) in humans. The coronavirus mouse hepatitis virus (MHV) infects mice and serves as an ideal model of viral pathogenesis, mainly because experiments can be conducted using animal-biosafety level-2 (A-BSL2) containment. Human thymosin beta-4 (Tbeta4), a 43-residue peptide with an acetylated N-terminus, is widely expressed in human tissues. Tbeta4 regulates actin polymerization and functions as an anti-inflammatory molecule and an antioxidant as well as a promoter of wound healing and angiogenesis. These activities led us to test whether Tbeta4 serves to treat coronavirus infections of humans. To test this possibility, here, we established a BALB/c mouse model of coronavirus infection using mouse CoV MHV-A59 to evaluate the potential protective effect of recombinant human Tbeta4 (rhTbeta4). Such a system can be employed under A-BSL2 containment instead of A-BSL3 that is required to study coronaviruses infectious for humans. We found that rhTbeta4 significantly increased the survival rate of mice infected with MHV-A59 through inhibiting virus replication, balancing the host's immune response, alleviating pathological damage, and promoting repair of the liver. These results will serve as the basis for further application of rhTbeta4 to the treatment of human CoV diseases such as COVID-19. |*Murine hepatitis virus/immunology[MESH] |Animals[MESH] |Antibodies, Viral/blood[MESH] |C-Reactive Protein/analysis[MESH] |Coronavirus Infections/*drug therapy[MESH] |Cytokines/blood[MESH] |Female[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |RNA, Viral/analysis[MESH] |Recombinant Proteins/therapeutic use[MESH] |Thymosin/*therapeutic use[MESH]Recombinant Human Thymosin Beta-4 Protects against Mouse Coronavirus I(epmc).pdf DeepDyve Pubget Overpricing