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10.1016/S2213-2600(21)00218-6 http://scihub22266oqcxt.onion/10.1016/S2213-2600(21)00218-6 33965003!8102044!33965003     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33965003&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Respir+Med 2021 ; 9 (6): 622-642 Nephropedia Template TP {{tp|p=33965003|t=2021. The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity |pdf=|usr=}}{{33965003}} gab.com Text The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity JO: Lancet Respir Med http://www.kidney.de/pget.php?&tw=1&pmid=33965003 #FOAvip The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19. Twit Text FOAVip The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity ????Lancet Respir Med http://www.kidney.de/pget.php?&tw=1&pmid=33965003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33965003 #FOAvip English Wikipedia <ref>{{Cite pmid|33965003}}</ref> The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity #MMPMID33965003 Osuchowski MF; Winkler MS; Skirecki T; Cajander S; Shankar-Hari M; Lachmann G; Monneret G; Venet F; Bauer M; Brunkhorst FM; Weis S; Garcia-Salido A; Kox M; Cavaillon JM; Uhle F; Weigand MA; Flohe SB; Wiersinga WJ; Almansa R; de la Fuente A; Martin-Loeches I; Meisel C; Spinetti T; Schefold JC; Cilloniz C; Torres A; Giamarellos-Bourboulis EJ; Ferrer R; Girardis M; Cossarizza A; Netea MG; van der Poll T; Bermejo-Martin JF; Rubio I Lancet Respir Med 2021[Jun]; 9 (6): 622-642 PMID33965003show ga The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19. |*COVID-19/immunology/physiopathology[MESH] |*Multiple Organ Failure/etiology/physiopathology[MESH] |Endothelium/physiopathology[MESH] |Humans[MESH] |Immunity[MESH] |Patient Acuity[MESH] |SARS-CoV-2/*pathogenicity[MESH]The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a n(epmc).pdf DeepDyve Pubget Overpricing