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10.1038/s41598-021-89379-x http://scihub22266oqcxt.onion/10.1038/s41598-021-89379-x 33963249!8105332!33963249     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 9803 Nephropedia Template TP {{tp|p=33963249|t=2021. Angiotensin converting enzyme 2 is a novel target of the gamma-secretase complex |pdf=|usr=}}{{33963249}} gab.com Text Angiotensin converting enzyme 2 is a novel target of the gamma-secretase complex JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33963249 #FOAvip Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin-angiotensin system, but also the functional receptor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on structural similarity with other gamma-secretase (gammaS) targets, we hypothesized that ACE2 may be affected by gammaS proteolytic activity. We found that after ectodomain shedding, ACE2 is targeted for intramembrane proteolysis by gammaS, releasing a soluble ACE2 C-terminal fragment. Consistently, chemical or genetic inhibition of gammaS results in the accumulation of a membrane-bound fragment of ectodomain-deficient ACE2. Although chemical inhibition of gammaS does not alter SARS-CoV-2 cell entry, these data point to a novel pathway for cellular ACE2 trafficking. Twit Text FOAVip Angiotensin converting enzyme 2 is a novel target of the gamma-secretase complex ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33963249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33963249 #FOAvip English Wikipedia <ref>{{Cite pmid|33963249}}</ref> Angiotensin converting enzyme 2 is a novel target of the gamma-secretase complex #MMPMID33963249 Bartolome A; Liang J; Wang P; Ho DD; Pajvani UB Sci Rep 2021[May]; 11 (1): 9803 PMID33963249show ga Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin-angiotensin system, but also the functional receptor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on structural similarity with other gamma-secretase (gammaS) targets, we hypothesized that ACE2 may be affected by gammaS proteolytic activity. We found that after ectodomain shedding, ACE2 is targeted for intramembrane proteolysis by gammaS, releasing a soluble ACE2 C-terminal fragment. Consistently, chemical or genetic inhibition of gammaS results in the accumulation of a membrane-bound fragment of ectodomain-deficient ACE2. Although chemical inhibition of gammaS does not alter SARS-CoV-2 cell entry, these data point to a novel pathway for cellular ACE2 trafficking. |Amyloid Precursor Protein Secretases/genetics/*metabolism[MESH] |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Animals[MESH] |COVID-19/genetics/*metabolism[MESH] |Caco-2 Cells[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Gene Knockout Techniques[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Membrane Glycoproteins/genetics/*metabolism[MESH] |Mice[MESH] |Presenilin-1/genetics/*metabolism[MESH] |Presenilin-2/genetics/*metabolism[MESH] |Proteolysis[MESH] |SARS-CoV-2/*physiology[MESH] |Vero Cells[MESH]Angiotensin converting enzyme 2 is a novel target of the gamma-secreta(epmc).pdf DeepDyve Pubget Overpricing