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10.1128/JCM.00319-21

http://scihub22266oqcxt.onion/10.1128/JCM.00319-21
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suck abstract from ncbi


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pmid33962959      J+Clin+Microbiol 2021 ; 59 (8): e0031921
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  • Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests, and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum #MMPMID33962959
  • Krone M; Gutling J; Wagener J; Lam TT; Schoen C; Vogel U; Stich A; Wedekink F; Wischhusen J; Kerkau T; Beyersdorf N; Klingler S; Backes S; Dolken L; Gasteiger G; Kurzai O; Schubert-Unkmeir A
  • J Clin Microbiol 2021[Jul]; 59 (8): e0031921 PMID33962959show ga
  • For the control of immunity in COVID-19 survivors and vaccinated subjects, there is an urgent need for reliable and rapid serological assays. Based on samples from 63 COVID-19 survivors up to 7 months after symptom onset, and on 50 serum samples taken before the beginning of the pandemic, we compared the performances of three commercial immunoassays for the detection of SARS-CoV-2 IgA and IgG antibodies (Euroimmun SARS-COV-2 IgA/IgG, Mikrogen recomWell SARS-CoV-2 IgA/IgG, and Serion ELISA agile SARS-CoV-2 IgA/IgG) and three rapid lateral flow (immunochromatographic) tests (Abbott PanBio COVID-19 IgG/IgM, Nadal COVID-19 IgG/IgM, and Cleartest Corona 2019-nCOV IgG/IgM) with a 50% plaque-reduction neutralization test (PRNT50) representing the gold standard. Fifty-seven out of 63 PCR-confirmed COVID-19 patients (90%) showed neutralizing antibodies. The sensitivity of the seven assays ranged from 7.0% to 98.3%, and the specificity ranged from 86.0% to 100.0%. Only one commercial immunoassay showed a sensitivity and specificity of greater than 98%.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Viral[MESH]
  • |Humans[MESH]
  • |Immunoassay[MESH]
  • |Immunoglobulin M[MESH]
  • |Pandemics[MESH]


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