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10.15252/emmm.202114045 http://scihub22266oqcxt.onion/10.15252/emmm.202114045 33961735!8185544!33961735     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2021 ; 13 (6): e14045 Nephropedia Template TP {{tp|p=33961735|t=2021. Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2 |pdf=|usr=}}{{33961735}} gab.com Text Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2 JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33961735 #FOAvip The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169(+) expressing monocytes in the peripheral blood. Systemic levels of pro-inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro-inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus-specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS-CoV-2 was observed in asymptomatic patients. In addition, asymptomatic COVID-19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro-inflammatory and more protective immune responses against SARS-CoV-2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID-19. Twit Text FOAVip Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2 ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33961735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33961735 #FOAvip English Wikipedia <ref>{{Cite pmid|33961735}}</ref> Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2 #MMPMID33961735 Chan YH; Fong SW; Poh CM; Carissimo G; Yeo NK; Amrun SN; Goh YS; Lim J; Xu W; Chee RS; Torres-Ruesta A; Lee CY; Tay MZ; Chang ZW; Lee WH; Wang B; Tan SY; Kalimuddin S; Young BE; Leo YS; Wang CI; Lee B; Rotzschke O; Lye DC; Renia L; Ng LFP EMBO Mol Med 2021[Jun]; 13 (6): e14045 PMID33961735show ga The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169(+) expressing monocytes in the peripheral blood. Systemic levels of pro-inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro-inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus-specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS-CoV-2 was observed in asymptomatic patients. In addition, asymptomatic COVID-19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro-inflammatory and more protective immune responses against SARS-CoV-2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID-19. |Biomarkers/metabolism[MESH] |Brain-Derived Neurotrophic Factor/metabolism[MESH] |COVID-19/immunology/*pathology/virology[MESH] |Carrier State/*immunology/pathology/virology[MESH] |Cytokines/metabolism[MESH] |Humans[MESH] |Monocytes/cytology/immunology/metabolism[MESH] |Neutrophils/cytology/immunology/metabolism[MESH] |SARS-CoV-2/isolation & purification[MESH] |Th17 Cells/cytology/immunology/metabolism[MESH] |Transcriptome[MESH] |Up-Regulation[MESH]Asymptomatic COVID-19: disease tolerance with efficient anti-viral imm(epmc).pdf DeepDyve Pubget Overpricing