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10.1093/infdis/jiab242

http://scihub22266oqcxt.onion/10.1093/infdis/jiab242
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suck abstract from ncbi


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pmid33961690      J+Infect+Dis 2021 ; 224 (2): 241-245
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  • Progressive and Parallel Decline of Humoral and T-Cell Immunity in Convalescent Healthcare Workers with Asymptomatic or Mild-to-Moderate Severe Acute Respiratory Syndrome Coronavirus 2 Infection #MMPMID33961690
  • Casado JL; Vizcarra P; Velasco H; Hammerle J; McGee A; Fernandez-Escribano M; Vallejo A
  • J Infect Dis 2021[Jul]; 224 (2): 241-245 PMID33961690show ga
  • We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P < .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection.
  • |*Convalescence[MESH]
  • |*Immunity, Humoral[MESH]
  • |Adaptive Immunity[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |Antigens, Viral/immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cytokines/immunology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Health Personnel/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/immunology[MESH]


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