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10.1002/1873-3468.14104 http://scihub22266oqcxt.onion/10.1002/1873-3468.14104 33961290!8209884!33961290     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Lett 2021 ; 595 (13): 1819-1824 Nephropedia Template TP {{tp|p=33961290|t=2021. Serum levels of the IgA isotype switch factor TGF-beta1 are elevated in patients with COVID-19 |pdf=|usr=}}{{33961290}} gab.com Text Serum levels of the IgA isotype switch factor TGF-beta1 are elevated in patients with COVID-19 JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=33961290 #FOAvip We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-beta1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-beta1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-beta1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-beta1 may play a key role in COVID-19. Twit Text FOAVip Serum levels of the IgA isotype switch factor TGF-beta1 are elevated in patients with COVID-19 ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=33961290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33961290 #FOAvip English Wikipedia <ref>{{Cite pmid|33961290}}</ref> Serum levels of the IgA isotype switch factor TGF-beta1 are elevated in patients with COVID-19 #MMPMID33961290 Wang EY; Chen H; Sun BQ; Wang H; Qu HQ; Liu Y; Sun XZ; Qu J; Fang ZF; Tian L; Zeng YF; Huang SK; Hakonarson H; Liu ZG FEBS Lett 2021[Jul]; 595 (13): 1819-1824 PMID33961290show ga We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-beta1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-beta1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-beta1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-beta1 may play a key role in COVID-19. |APACHE[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Viral/blood[MESH] |COVID-19/blood/genetics/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/*blood/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Polymorphism, Single Nucleotide[MESH] |SARS-CoV-2/*immunology[MESH] |Thrombospondins/*genetics[MESH]Serum levels of the IgA isotype switch factor TGF-beta1 are elevated i(epmc).pdf DeepDyve Pubget Overpricing