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10.1111/cpr.13046 http://scihub22266oqcxt.onion/10.1111/cpr.13046 33960563!8168420!33960563     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Prolif 2021 ; 54 (6): e13046 Nephropedia Template TP {{tp|p=33960563|t=2021. Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease |pdf=|usr=}}{{33960563}} gab.com Text Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease JO: Cell Prolif http://www.kidney.de/pget.php?&tw=1&pmid=33960563 #FOAvip OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage including chronic bronchitis and emphysema, which could further develop into respiratory failure. Many studies have revealed a potential regenerative function of the distal airway stem/progenitor cells (DASCs) after lung injury. MATERIALS AND METHODS: Mouse and human DASCs were expanded, analysed, and engrafted into injured mouse lungs. Single-cell analyses were performed to reveal the differentiation path of the engrafted cells. Finally, human DASCs were transplanted into COPD mice induced by porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS) administration. RESULTS: We showed that isolated mouse and human DASCs could be indefinitely expanded and were able to further differentiate into mature alveolar structures in vitro. Single-cell analysis indicated that the engrafted cells expressed typical cellular markers of type I alveolar cells as well as the specific secreted proteins. Interestingly, transplantation of human DASCs derived from COPD patients into the lungs of NOD-SCID mice with COPD injury repaired the tissue damage and improved the pulmonary function. CONCLUSIONS: The findings demonstrated that functional lung structure could be reconstituted by intrapulmonary transplantation of DASCs, suggesting a potential therapeutic role of DASCs transplantation in treatment for chronic obstructive pulmonary disease. Twit Text FOAVip Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease ????Cell Prolif http://www.kidney.de/pget.php?&tw=1&pmid=33960563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33960563 #FOAvip English Wikipedia <ref>{{Cite pmid|33960563}}</ref> Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease #MMPMID33960563 Wang X; Zhao Y; Li D; Feng Y; Xie Y; Zhou Y; Zhou M; Wang Y; Qu J; Zuo W Cell Prolif 2021[Jun]; 54 (6): e13046 PMID33960563show ga OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage including chronic bronchitis and emphysema, which could further develop into respiratory failure. Many studies have revealed a potential regenerative function of the distal airway stem/progenitor cells (DASCs) after lung injury. MATERIALS AND METHODS: Mouse and human DASCs were expanded, analysed, and engrafted into injured mouse lungs. Single-cell analyses were performed to reveal the differentiation path of the engrafted cells. Finally, human DASCs were transplanted into COPD mice induced by porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS) administration. RESULTS: We showed that isolated mouse and human DASCs could be indefinitely expanded and were able to further differentiate into mature alveolar structures in vitro. Single-cell analysis indicated that the engrafted cells expressed typical cellular markers of type I alveolar cells as well as the specific secreted proteins. Interestingly, transplantation of human DASCs derived from COPD patients into the lungs of NOD-SCID mice with COPD injury repaired the tissue damage and improved the pulmonary function. CONCLUSIONS: The findings demonstrated that functional lung structure could be reconstituted by intrapulmonary transplantation of DASCs, suggesting a potential therapeutic role of DASCs transplantation in treatment for chronic obstructive pulmonary disease. |*Stem Cell Transplantation[MESH] |Animals[MESH] |Female[MESH] |Heterografts[MESH] |Humans[MESH] |Lung/*metabolism/pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred NOD[MESH] |Mice, SCID[MESH] |Pulmonary Disease, Chronic Obstructive/metabolism/pathology/*therapy[MESH]Intrapulmonary distal airway stem cell transplantation repairs lung in(epmc).pdf DeepDyve Pubget Overpricing