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10.3389/fimmu.2021.639329 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.639329 33959123!8093414!33959123     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 639329 Nephropedia Template TP {{tp|p=33959123|t=2021. Circulating Adaptive Immune Cells Expressing the Gut Homing Marker alpha4beta7 Integrin Are Decreased in COVID-19 |pdf=|usr=}}{{33959123}} gab.com Text Circulating Adaptive Immune Cells Expressing the Gut Homing Marker alpha4beta7 Integrin Are Decreased in COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33959123 #FOAvip BACKGROUND: Infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a wide range of symptoms including gastrointestinal manifestations, and intestinal epithelial cells are a target of the virus. However, it is unknown how the intestinal immune system contributes to systemic immune responses in coronavirus disease 2019 (COVID-19). METHODS: We characterized peripheral blood lymphocytes from patients with active COVID-19 and convalescent patients as well as healthy controls by flow cytometry. RESULTS: The frequency and absolute number of circulating memory T and B cells expressing the gut homing integrin alpha4beta7 integrin was reduced during COVID-19, whether gastrointestinal symptoms were present or not. While total IgA-expressing B cells were increased, gut-imprinted B cells with IgA expression were stable. CONCLUSION: COVID-19 is associated with a decrease in circulating adaptive immune cells expressing the key gut homing marker alpha4beta7 suggesting that these cells are preferentially recruited to extra-intestinal tissues independently of alpha4beta7 or that the systemic immune response against SARS-CoV-2 is at least numerically dominated by extraintestinal, particularly pulmonary, immune cell priming. Twit Text FOAVip Circulating Adaptive Immune Cells Expressing the Gut Homing Marker alpha4beta7 Integrin Are Decreased in COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33959123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33959123 #FOAvip English Wikipedia <ref>{{Cite pmid|33959123}}</ref> Circulating Adaptive Immune Cells Expressing the Gut Homing Marker alpha4beta7 Integrin Are Decreased in COVID-19 #MMPMID33959123 Muller TM; Becker E; Wiendl M; Schulze LL; Voskens C; Volkl S; Kremer AE; Neurath MF; Zundler S Front Immunol 2021[]; 12 (ä): 639329 PMID33959123show ga BACKGROUND: Infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a wide range of symptoms including gastrointestinal manifestations, and intestinal epithelial cells are a target of the virus. However, it is unknown how the intestinal immune system contributes to systemic immune responses in coronavirus disease 2019 (COVID-19). METHODS: We characterized peripheral blood lymphocytes from patients with active COVID-19 and convalescent patients as well as healthy controls by flow cytometry. RESULTS: The frequency and absolute number of circulating memory T and B cells expressing the gut homing integrin alpha4beta7 integrin was reduced during COVID-19, whether gastrointestinal symptoms were present or not. While total IgA-expressing B cells were increased, gut-imprinted B cells with IgA expression were stable. CONCLUSION: COVID-19 is associated with a decrease in circulating adaptive immune cells expressing the key gut homing marker alpha4beta7 suggesting that these cells are preferentially recruited to extra-intestinal tissues independently of alpha4beta7 or that the systemic immune response against SARS-CoV-2 is at least numerically dominated by extraintestinal, particularly pulmonary, immune cell priming. |Adult[MESH] |B-Lymphocytes/immunology/*metabolism[MESH] |Biomarkers/analysis[MESH] |COVID-19/*immunology/pathology[MESH] |Female[MESH] |Humans[MESH] |Immunologic Memory/immunology[MESH] |Integrin alpha4/*metabolism[MESH] |Integrins/*metabolism[MESH] |Intestinal Mucosa/cytology/immunology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology[MESH]Circulating Adaptive Immune Cells Expressing the Gut Homing Marker alp(epmc).pdf DeepDyve Pubget Overpricing