Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41385-021-00404-8 http://scihub22266oqcxt.onion/10.1038/s41385-021-00404-8 33958704!8100369!33958704     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mucosal+Immunol 2021 ; 14 (6): 1224-1234 Nephropedia Template TP {{tp|p=33958704|t=2021. Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution |pdf=|usr=}}{{33958704}} gab.com Text Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33958704 #FOAvip Epidemiological evidence establishes obesity as an independent risk factor for increased susceptibility and severity to viral respiratory pneumonias associated with H1N1 influenza and SARS-CoV-2 pandemics. Given the global obesity prevalence, a better understanding of the mechanisms behind obese susceptibility to infection is imperative. Altered immune cell metabolism and function are often perceived as a key causative factor of dysregulated inflammation. However, the contribution of adipocytes, the dominantly altered cell type in obesity with broad inflammatory properties, to infectious disease pathogenesis remains largely ignored. Thus, skewing of adipocyte-intrinsic cellular metabolism may lead to the development of pathogenic inflammatory adipocytes, which shape the overall immune responses by contributing to either premature immunosenescence, delayed hyperinflammation, or cytokine storm in infections. In this review, we discuss the underappreciated contribution of adipocyte cellular metabolism and adipocyte-produced mediators on immune system modulation and how such interplay may modify disease susceptibility and pathogenesis of influenza and SARS-CoV-2 infections in obese individuals. Twit Text FOAVip Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33958704 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33958704 #FOAvip English Wikipedia <ref>{{Cite pmid|33958704}}</ref> Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution #MMPMID33958704 Alarcon PC; Damen MSMA; Madan R; Deepe GS Jr; Spearman P; Way SS; Divanovic S Mucosal Immunol 2021[Nov]; 14 (6): 1224-1234 PMID33958704show ga Epidemiological evidence establishes obesity as an independent risk factor for increased susceptibility and severity to viral respiratory pneumonias associated with H1N1 influenza and SARS-CoV-2 pandemics. Given the global obesity prevalence, a better understanding of the mechanisms behind obese susceptibility to infection is imperative. Altered immune cell metabolism and function are often perceived as a key causative factor of dysregulated inflammation. However, the contribution of adipocytes, the dominantly altered cell type in obesity with broad inflammatory properties, to infectious disease pathogenesis remains largely ignored. Thus, skewing of adipocyte-intrinsic cellular metabolism may lead to the development of pathogenic inflammatory adipocytes, which shape the overall immune responses by contributing to either premature immunosenescence, delayed hyperinflammation, or cytokine storm in infections. In this review, we discuss the underappreciated contribution of adipocyte cellular metabolism and adipocyte-produced mediators on immune system modulation and how such interplay may modify disease susceptibility and pathogenesis of influenza and SARS-CoV-2 infections in obese individuals. |Adipocytes/*metabolism/pathology/virology[MESH] |COVID-19/*metabolism/pathology[MESH] |Humans[MESH] |Inflammation/metabolism/pathology/virology[MESH] |Influenza A Virus, H1N1 Subtype/*metabolism[MESH] |Influenza, Human/*metabolism/pathology[MESH]Adipocyte inflammation and pathogenesis of viral pneumonias: an overlo(epmc).pdf DeepDyve Pubget Overpricing