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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mayo+Clin+Proc 2021 ; 96 (5): 1262-1275 Nephropedia Template TP
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The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis #MMPMID33958057
Klassen SA; Senefeld JW; Johnson PW; Carter RE; Wiggins CC; Shoham S; Grossman BJ; Henderson JP; Musser J; Salazar E; Hartman WR; Bouvier NM; Liu STH; Pirofski LA; Baker SE; van Helmond N; Wright RS; Fairweather D; Bruno KA; Wang Z; Paneth NS; Casadevall A; Joyner MJ
Mayo Clin Proc 2021[May]; 96 (5): 1262-1275 PMID33958057show ga
To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.