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10.1016/j.mayocp.2021.02.008

http://scihub22266oqcxt.onion/10.1016/j.mayocp.2021.02.008
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33958057!7888247!33958057
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suck abstract from ncbi


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pmid33958057      Mayo+Clin+Proc 2021 ; 96 (5): 1262-1275
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  • The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis #MMPMID33958057
  • Klassen SA; Senefeld JW; Johnson PW; Carter RE; Wiggins CC; Shoham S; Grossman BJ; Henderson JP; Musser J; Salazar E; Hartman WR; Bouvier NM; Liu STH; Pirofski LA; Baker SE; van Helmond N; Wright RS; Fairweather D; Bruno KA; Wang Z; Paneth NS; Casadevall A; Joyner MJ
  • Mayo Clin Proc 2021[May]; 96 (5): 1262-1275 PMID33958057show ga
  • To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/mortality/*therapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/methods[MESH]
  • |Mortality[MESH]
  • |SARS-CoV-2/immunology[MESH]


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