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10.1093/bib/bbab169 http://scihub22266oqcxt.onion/10.1093/bib/bbab169 33956950!8136014!33956950     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (6): ä Nephropedia Template TP {{tp|p=33956950|t=2021. The peripheral and core regions of virus-host network of COVID-19 |pdf=|usr=}}{{33956950}} gab.com Text The peripheral and core regions of virus-host network of COVID-19 JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33956950 #FOAvip Two thousand nineteen novel coronavirus SARS-CoV-2, the pathogen of COVID-19, has caused a catastrophic pandemic, which has a profound and widespread impact on human lives and social economy globally. However, the molecular perturbations induced by the SARS-CoV-2 infection remain unknown. In this paper, from the perspective of omnigenic, we analyze the properties of the neighborhood perturbed by SARS-CoV-2 in the human interactome and disclose the peripheral and core regions of virus-host network (VHN). We find that the virus-host proteins (VHPs) form a significantly connected VHN, among which highly perturbed proteins aggregate into an observable core region. The non-core region of VHN forms a large scale but relatively low perturbed periphery. We further validate that the periphery is non-negligible and conducive to identifying comorbidities and detecting drug repurposing candidates for COVID-19. We particularly put forward a flower model for COVID-19, SARS and H1N1 based on their peripheral regions, and the flower model shows more correlations between COVID-19 and other two similar diseases in common functional pathways and candidate drugs. Overall, our periphery-core pattern can not only offer insights into interconnectivity of SARS-CoV-2 VHPs but also facilitate the research on therapeutic drugs. Twit Text FOAVip The peripheral and core regions of virus-host network of COVID-19 ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33956950 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33956950 #FOAvip English Wikipedia <ref>{{Cite pmid|33956950}}</ref> The peripheral and core regions of virus-host network of COVID-19 #MMPMID33956950 Wang B; Dong X; Hu J; Ma X; Han C; Wang Y; Gao L Brief Bioinform 2021[Nov]; 22 (6): ä PMID33956950show ga Two thousand nineteen novel coronavirus SARS-CoV-2, the pathogen of COVID-19, has caused a catastrophic pandemic, which has a profound and widespread impact on human lives and social economy globally. However, the molecular perturbations induced by the SARS-CoV-2 infection remain unknown. In this paper, from the perspective of omnigenic, we analyze the properties of the neighborhood perturbed by SARS-CoV-2 in the human interactome and disclose the peripheral and core regions of virus-host network (VHN). We find that the virus-host proteins (VHPs) form a significantly connected VHN, among which highly perturbed proteins aggregate into an observable core region. The non-core region of VHN forms a large scale but relatively low perturbed periphery. We further validate that the periphery is non-negligible and conducive to identifying comorbidities and detecting drug repurposing candidates for COVID-19. We particularly put forward a flower model for COVID-19, SARS and H1N1 based on their peripheral regions, and the flower model shows more correlations between COVID-19 and other two similar diseases in common functional pathways and candidate drugs. Overall, our periphery-core pattern can not only offer insights into interconnectivity of SARS-CoV-2 VHPs but also facilitate the research on therapeutic drugs. |*Drug Repositioning[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*genetics/pathology/virology[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/drug effects/pathogenicity[MESH]The peripheral and core regions of virus-host network of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing