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10.1371/journal.pcbi.1008849 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1008849 33956791!8101958!33956791     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Comput+Biol 2021 ; 17 (5): e1008849 Nephropedia Template TP {{tp|p=33956791|t=2021. Modelling optimal vaccination strategy for SARS-CoV-2 in the UK |pdf=|usr=}}{{33956791}} gab.com Text Modelling optimal vaccination strategy for SARS-CoV-2 in the UK JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=33956791 #FOAvip The COVID-19 outbreak has highlighted our vulnerability to novel infections. Faced with this threat and no effective treatment, in line with many other countries, the UK adopted enforced social distancing (lockdown) to reduce transmission-successfully reducing the reproductive number R below one. However, given the large pool of susceptible individuals that remain, complete relaxation of controls is likely to generate a substantial further outbreak. Vaccination remains the only foreseeable means of both containing the infection and returning to normal interactions and behaviour. Here, we consider the optimal targeting of vaccination within the UK, with the aim of minimising future deaths or quality adjusted life year (QALY) losses. We show that, for a range of assumptions on the action and efficacy of the vaccine, targeting older age groups first is optimal and may be sufficient to stem the epidemic if the vaccine prevents transmission as well as disease. Twit Text FOAVip Modelling optimal vaccination strategy for SARS-CoV-2 in the UK ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=33956791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33956791 #FOAvip English Wikipedia <ref>{{Cite pmid|33956791}}</ref> Modelling optimal vaccination strategy for SARS-CoV-2 in the UK #MMPMID33956791 Moore S; Hill EM; Dyson L; Tildesley MJ; Keeling MJ PLoS Comput Biol 2021[May]; 17 (5): e1008849 PMID33956791show ga The COVID-19 outbreak has highlighted our vulnerability to novel infections. Faced with this threat and no effective treatment, in line with many other countries, the UK adopted enforced social distancing (lockdown) to reduce transmission-successfully reducing the reproductive number R below one. However, given the large pool of susceptible individuals that remain, complete relaxation of controls is likely to generate a substantial further outbreak. Vaccination remains the only foreseeable means of both containing the infection and returning to normal interactions and behaviour. Here, we consider the optimal targeting of vaccination within the UK, with the aim of minimising future deaths or quality adjusted life year (QALY) losses. We show that, for a range of assumptions on the action and efficacy of the vaccine, targeting older age groups first is optimal and may be sufficient to stem the epidemic if the vaccine prevents transmission as well as disease. |*Computer Simulation[MESH] |*Vaccination[MESH] |COVID-19 Vaccines/*administration & dosage[MESH] |COVID-19/epidemiology/*immunology/prevention & control/transmission[MESH] |Communicable Disease Control[MESH] |Humans[MESH] |Immunity, Herd[MESH]Modelling optimal vaccination strategy for SARS-CoV-2 in the UK (epmc).pdf DeepDyve Pubget Overpricing