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Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 MMWR+Morb+Mortal+Wkly+Rep 2021 ; 70 (18): 674-679 Nephropedia Template TP
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Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged /=65 Years - United States, January-March 2021 #MMPMID33956782
Tenforde MW; Olson SM; Self WH; Talbot HK; Lindsell CJ; Steingrub JS; Shapiro NI; Ginde AA; Douin DJ; Prekker ME; Brown SM; Peltan ID; Gong MN; Mohamed A; Khan A; Exline MC; Files DC; Gibbs KW; Stubblefield WB; Casey JD; Rice TW; Grijalva CG; Hager DN; Shehu A; Qadir N; Chang SY; Wilson JG; Gaglani M; Murthy K; Calhoun N; Monto AS; Martin ET; Malani A; Zimmerman RK; Silveira FP; Middleton DB; Zhu Y; Wyatt D; Stephenson M; Baughman A; Womack KN; Hart KW; Kobayashi M; Verani JR; Patel MM
Adults aged >/=65 years are at increased risk for severe outcomes from COVID-19 and were identified as a priority group to receive the first COVID-19 vaccines approved for use under an Emergency Use Authorization (EUA) in the United States (1-3). In an evaluation at 24 hospitals in 14 states,* the effectiveness of partial or full vaccination(dagger) with Pfizer-BioNTech or Moderna vaccines against COVID-19-associated hospitalization was assessed among adults aged >/=65 years. Among 417 hospitalized adults aged >/=65 years (including 187 case-patients and 230 controls), the median age was 73 years, 48% were female, 73% were non-Hispanic White, 17% were non-Hispanic Black, 6% were Hispanic, and 4% lived in a long-term care facility. Adjusted vaccine effectiveness (VE) against COVID-19-associated hospitalization among adults aged >/=65 years was estimated to be 94% (95% confidence interval [CI] = 49%-99%) for full vaccination and 64% (95% CI = 28%-82%) for partial vaccination. These findings are consistent with efficacy determined from clinical trials in the subgroup of adults aged >/=65 years (4,5). This multisite U.S. evaluation under real-world conditions suggests that vaccination provided protection against COVID-19-associated hospitalization among adults aged >/=65 years. Vaccination is a critical tool for reducing severe COVID-19 in groups at high risk.