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10.1099/jgv.0.001593 http://scihub22266oqcxt.onion/10.1099/jgv.0.001593 33956593!ä!33956593 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2021 ; 102 (5): ä Nephropedia Template TP {{tp|p=33956593|t=2021. Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells |pdf=|usr=}}{{33956593}} gab.com Text Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=33956593 #FOAvip Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a bronchial epithelial cell line. Most lipid features were downregulated for both influenza virus and rhinovirus, especially for the sphingomyelin features. Pathway analysis showed that sphingolipid metabolism was the most perturbed pathway. Functional study showed that bacterial sphingomyelinase suppressed influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication, but promoted rhinovirus replication. These findings suggest that sphingomyelin pathway can be a potential target for antiviral therapy, but should be carefully evaluated as it has opposite effects on different respiratory viruses. Furthermore, the differential effect of sphingomyelinase on rhinovirus and influenza virus may explain the interference between rhinovirus and influenza virus infection. Twit Text FOAVip Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=33956593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33956593 #FOAvip English Wikipedia <ref>{{Cite pmid|33956593}}</ref> Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells #MMPMID33956593 Dissanayake TK; Yan B; Ng AC; Zhao H; Chan G; Yip CC; Sze KH; To KK J Gen Virol 2021[May]; 102 (5): ä PMID33956593show ga Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a bronchial epithelial cell line. Most lipid features were downregulated for both influenza virus and rhinovirus, especially for the sphingomyelin features. Pathway analysis showed that sphingolipid metabolism was the most perturbed pathway. Functional study showed that bacterial sphingomyelinase suppressed influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication, but promoted rhinovirus replication. These findings suggest that sphingomyelin pathway can be a potential target for antiviral therapy, but should be carefully evaluated as it has opposite effects on different respiratory viruses. Furthermore, the differential effect of sphingomyelinase on rhinovirus and influenza virus may explain the interference between rhinovirus and influenza virus infection. |Animals[MESH] |Bronchial Diseases/virology[MESH] |COVID-19 Drug Treatment[MESH] |Cell Line[MESH] |Dogs[MESH] |Epithelial Cells/virology[MESH] |Humans[MESH] |Influenza, Human[MESH] |Lipidomics[MESH] |Madin Darby Canine Kidney Cells[MESH] |Orthomyxoviridae Infections/drug therapy[MESH] |Orthomyxoviridae/*drug effects[MESH] |Rhinovirus/*drug effects[MESH] |SARS-CoV-2/*drug effects[MESH] |Sphingomyelin Phosphodiesterase[MESH] |Sphingomyelins/*pharmacology[MESH]Differential role of sphingomyelin in influenza virus, rhinovirus and (epmc).pdf DeepDyve Pubget Overpricing