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10.1007/s42770-021-00497-0

http://scihub22266oqcxt.onion/10.1007/s42770-021-00497-0
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suck abstract from ncbi


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pmid33956332      Braz+J+Microbiol 2021 ; 52 (3): 1151-1159
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  • Functional and tissue enrichment analyses suggest that SARS-CoV-2 infection affects host metabolism and catabolism mediated by interference on host proteins #MMPMID33956332
  • Lopes LR
  • Braz J Microbiol 2021[Sep]; 52 (3): 1151-1159 PMID33956332show ga
  • Infection by SARS-CoV-2, the causative agent of COVID-19, is critically connected with host metabolism. Through functional enrichment analysis, the present study aims to evaluate the biological processes involving host proteins interfered by SARS-CoV-2 to verify the potential metabolic impact of the infection. Furthermore, tissue enrichment analyses and differential gene expression of host proteins were applied to understand the interference by SARS-CoV-2 on tissue levels. Results based on functional and tissue-specific enrichment analyses, presented in this study, suggest that SARS-CoV-2, mediated interference on host proteins, can affect the metabolism and catabolism of molecular building blocks and control intracellular mechanisms, including gene expression in metabolism-related organs, to support viral demands. Thus, SARS-CoV-2 can broadly affect the host metabolism and catabolism at tissue and physiological levels contributing to a more severe disease.
  • |COVID-19/immunology/*metabolism[MESH]
  • |Energy Metabolism[MESH]
  • |Gene Expression[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Protein Interaction Maps[MESH]
  • |Proteins/genetics/metabolism[MESH]


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