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10.1038/s41591-021-01355-0 http://scihub22266oqcxt.onion/10.1038/s41591-021-01355-0 33953384!8785364!33953384     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2021 ; 27 (7): 1178-1186 Nephropedia Template TP {{tp|p=33953384|t=2021. Delayed production of neutralizing antibodies correlates with fatal COVID-19 |pdf=|usr=}}{{33953384}} gab.com Text Delayed production of neutralizing antibodies correlates with fatal COVID-19 JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33953384 #FOAvip Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses that govern COVID-19 disease outcomes remain unclear. In this study, we analyzed humoral immune responses in 229 patients with asymptomatic, mild, moderate and severe COVID-19 over time to probe the nature of antibody responses in disease severity and mortality. We observed a correlation between anti-spike (S) immunoglobulin G (IgG) levels, length of hospitalization and clinical parameters associated with worse clinical progression. Although high anti-S IgG levels correlated with worse disease severity, such correlation was time dependent. Deceased patients did not have higher overall humoral response than discharged patients. However, they mounted a robust, yet delayed, response, measured by anti-S, anti-receptor-binding domain IgG and neutralizing antibody (NAb) levels compared to survivors. Delayed seroconversion kinetics correlated with impaired viral control in deceased patients. Finally, although sera from 85% of patients displayed some neutralization capacity during their disease course, NAb generation before 14 d of disease onset emerged as a key factor for recovery. These data indicate that COVID-19 mortality does not correlate with the cross-sectional antiviral antibody levels per se but, rather, with the delayed kinetics of NAb production. Twit Text FOAVip Delayed production of neutralizing antibodies correlates with fatal COVID-19 ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33953384 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33953384 #FOAvip English Wikipedia <ref>{{Cite pmid|33953384}}</ref> Delayed production of neutralizing antibodies correlates with fatal COVID-19 #MMPMID33953384 Lucas C; Klein J; Sundaram ME; Liu F; Wong P; Silva J; Mao T; Oh JE; Mohanty S; Huang J; Tokuyama M; Lu P; Venkataraman A; Park A; Israelow B; Vogels CBF; Muenker MC; Chang CH; Casanovas-Massana A; Moore AJ; Zell J; Fournier JB; Wyllie AL; Campbell M; Lee AI; Chun HJ; Grubaugh ND; Schulz WL; Farhadian S; Dela Cruz C; Ring AM; Shaw AC; Wisnewski AV; Yildirim I; Ko AI; Omer SB; Iwasaki A Nat Med 2021[Jul]; 27 (7): 1178-1186 PMID33953384show ga Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses that govern COVID-19 disease outcomes remain unclear. In this study, we analyzed humoral immune responses in 229 patients with asymptomatic, mild, moderate and severe COVID-19 over time to probe the nature of antibody responses in disease severity and mortality. We observed a correlation between anti-spike (S) immunoglobulin G (IgG) levels, length of hospitalization and clinical parameters associated with worse clinical progression. Although high anti-S IgG levels correlated with worse disease severity, such correlation was time dependent. Deceased patients did not have higher overall humoral response than discharged patients. However, they mounted a robust, yet delayed, response, measured by anti-S, anti-receptor-binding domain IgG and neutralizing antibody (NAb) levels compared to survivors. Delayed seroconversion kinetics correlated with impaired viral control in deceased patients. Finally, although sera from 85% of patients displayed some neutralization capacity during their disease course, NAb generation before 14 d of disease onset emerged as a key factor for recovery. These data indicate that COVID-19 mortality does not correlate with the cross-sectional antiviral antibody levels per se but, rather, with the delayed kinetics of NAb production. |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19 Vaccines/therapeutic use[MESH] |COVID-19/*immunology/mortality/prevention & control[MESH] |Carrier State/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Humoral[MESH] |Immunoglobulin G/*immunology[MESH] |Kinetics[MESH] |Length of Stay/statistics & numerical data[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH]Delayed production of neutralizing antibodies correlates with fatal CO(epmc).pdf DeepDyve Pubget Overpricing