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10.1038/s12276-021-00592-0 http://scihub22266oqcxt.onion/10.1038/s12276-021-00592-0 33953323!8099704!33953323     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33953323.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Mol+Med 2021 ; 53 (5): 750-760 Nephropedia Template TP {{tp|p=33953323|t=2021. Type I and III interferon responses in SARS-CoV-2 infection |pdf=|usr=}}{{33953323}} gab.com Text Type I and III interferon responses in SARS-CoV-2 infection JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33953323 #FOAvip Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III interferons (IFNs) are innate cytokines that are important in the first-line defense against viruses. Similar to many other viruses, SARS-CoV-2 has evolved mechanisms for evading the antiviral effects of type I and III IFNs at multiple levels, including the induction of IFN expression and cellular responses to IFNs. In this review, we describe the innate sensing mechanisms of SARS-CoV-2 and the mechanisms used by SARS-CoV-2 to evade type I and III IFN responses. We also discuss contradictory reports regarding impaired and robust type I IFN responses in patients with severe COVID-19. Finally, we discuss how delayed but exaggerated type I IFN responses can exacerbate inflammation and contribute to the severe progression of COVID-19. Twit Text FOAVip Type I and III interferon responses in SARS-CoV-2 infection ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33953323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33953323 #FOAvip English Wikipedia <ref>{{Cite pmid|33953323}}</ref> Type I and III interferon responses in SARS-CoV-2 infection #MMPMID33953323 Kim YM; Shin EC Exp Mol Med 2021[May]; 53 (5): 750-760 PMID33953323show ga Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III interferons (IFNs) are innate cytokines that are important in the first-line defense against viruses. Similar to many other viruses, SARS-CoV-2 has evolved mechanisms for evading the antiviral effects of type I and III IFNs at multiple levels, including the induction of IFN expression and cellular responses to IFNs. In this review, we describe the innate sensing mechanisms of SARS-CoV-2 and the mechanisms used by SARS-CoV-2 to evade type I and III IFN responses. We also discuss contradictory reports regarding impaired and robust type I IFN responses in patients with severe COVID-19. Finally, we discuss how delayed but exaggerated type I IFN responses can exacerbate inflammation and contribute to the severe progression of COVID-19. |*Immune Evasion[MESH] |*Immunity, Innate[MESH] |Animals[MESH] |COVID-19/genetics/*immunology[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Inflammation/genetics/immunology[MESH] |Interferon Lambda[MESH] |Interferon Type I/genetics/*immunology[MESH] |Interferons/genetics/*immunology[MESH]Type I and III interferon responses in SARS-CoV-2 infection (epmc).pdf DeepDyve Pubget Overpricing