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10.1128/JCM.00079-21

http://scihub22266oqcxt.onion/10.1128/JCM.00079-21
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33952598!8373212!33952598
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suck abstract from ncbi


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pmid33952598      J+Clin+Microbiol 2021 ; 59 (8): e0007921
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  • Genomic Elucidation of a COVID-19 Resurgence and Local Transmission of SARS-CoV-2 in Guangzhou, China #MMPMID33952598
  • Jia HL; Li P; Liu HJ; Zhong JY; Qin PZ; Su WZ; Zheng YF; Li KB; Zeng Q; Li JH; Li LZ; Cao L; Wu JB; Chen YY; Jia LL; Song HB; Zhang QW; Yang G; Jing CX; Bo XC; Zhang ZB; Di B; Xiao CL; Ni M
  • J Clin Microbiol 2021[Jul]; 59 (8): e0007921 PMID33952598show ga
  • While China experienced a peak and decline in coronavirus disease 2019 (COVID-19) cases at the start of 2020, regional outbreaks continuously emerged in subsequent months. Resurgences of COVID-19 have also been observed in many other countries. In Guangzhou, China, a small outbreak, involving less than 100 residents, emerged in March and April 2020, and comprehensive and near-real-time genomic surveillance of SARS-CoV-2 was conducted. When the numbers of confirmed cases among overseas travelers increased, public health measures were enhanced by shifting from self-quarantine to central quarantine and SARS-CoV-2 testing for all overseas travelers. In an analysis of 109 imported cases, we found diverse viral variants distributed in the global viral phylogeny, which were frequently shared within households but not among passengers on the same flight. In contrast to the viral diversity of imported cases, local transmission was predominately attributed to two specific variants imported from Africa, including local cases that reported no direct or indirect contact with imported cases. The introduction events of the virus were identified or deduced before the enhanced measures were taken. These results show the interventions were effective in containing the spread of SARS-CoV-2, and they rule out the possibility of cryptic transmission of viral variants from the first wave in January and February 2020. Our study provides evidence and emphasizes the importance of controls for overseas travelers in the context of the pandemic and exemplifies how viral genomic data can facilitate COVID-19 surveillance and inform public health mitigation strategies.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Africa[MESH]
  • |COVID-19 Testing[MESH]
  • |China/epidemiology[MESH]
  • |Genomics[MESH]


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