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10.1016/j.intimp.2021.107685 http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107685 33951560!8052478!33951560     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2021 ; 97 (ä): 107685 Nephropedia Template TP {{tp|p=33951560|t=2021. Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients |pdf=|usr=}}{{33951560}} gab.com Text Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33951560 #FOAvip BACKGROUND: The 2019 Coronavirus (COVID-19) pandemic poses a huge threat internationally; however, the role of the host immune system in the pathogenesis of COVID-19 is not well understood. METHODS: Cytokine and chemokine levels and characterisation of immune cell subsets from 20 COVID-19 cases after hospital admission (17 critically ill and 3 severe patients) and 16 convalescent patients were determined using a multiplex immunoassay and flow cytometry, respectively. RESULTS: IP-10, MCP-1, MIG, IL-6, and IL-10 levels were significantly higher in acute severe/critically ill patients with COVID-19, whereas were normal in patients who had reached convalescence. CD8 T cells in severe and critically ill COVID-19 patients expressed high levels of cytotoxic granules (granzyme B and perforin)and was hyperactivated as evidenced by the high proportions of CD38. Furthermore, the cytotoxic potential of natural killer (NK) cells, and the frequencies of myeloid dendritic cells and plasmacytoid dendritic cells was reduced in patients with severe and critical COVID-19; however, these dysregulations were found to be restored in convalescent phases. CONCLUSION: Thus, elicitation of the hyperactive cytokine-mediated inflammatory response, dysregulation of CD8 T and NK cells, and deficiency of host myeloid and plasmacytoid DCs, may contribute to COVID-19 pathogenesis and provide insights into potential therapeutic targets and strategies. Twit Text FOAVip Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33951560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33951560 #FOAvip English Wikipedia <ref>{{Cite pmid|33951560}}</ref> Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients #MMPMID33951560 Chen Q; Yu B; Yang Y; Huang J; Liang Y; Zhou J; Li L; Peng X; Cheng B; Lin Y Int Immunopharmacol 2021[Aug]; 97 (ä): 107685 PMID33951560show ga BACKGROUND: The 2019 Coronavirus (COVID-19) pandemic poses a huge threat internationally; however, the role of the host immune system in the pathogenesis of COVID-19 is not well understood. METHODS: Cytokine and chemokine levels and characterisation of immune cell subsets from 20 COVID-19 cases after hospital admission (17 critically ill and 3 severe patients) and 16 convalescent patients were determined using a multiplex immunoassay and flow cytometry, respectively. RESULTS: IP-10, MCP-1, MIG, IL-6, and IL-10 levels were significantly higher in acute severe/critically ill patients with COVID-19, whereas were normal in patients who had reached convalescence. CD8 T cells in severe and critically ill COVID-19 patients expressed high levels of cytotoxic granules (granzyme B and perforin)and was hyperactivated as evidenced by the high proportions of CD38. Furthermore, the cytotoxic potential of natural killer (NK) cells, and the frequencies of myeloid dendritic cells and plasmacytoid dendritic cells was reduced in patients with severe and critical COVID-19; however, these dysregulations were found to be restored in convalescent phases. CONCLUSION: Thus, elicitation of the hyperactive cytokine-mediated inflammatory response, dysregulation of CD8 T and NK cells, and deficiency of host myeloid and plasmacytoid DCs, may contribute to COVID-19 pathogenesis and provide insights into potential therapeutic targets and strategies. |*Convalescence[MESH] |ADP-ribosyl Cyclase 1/blood[MESH] |Acute Disease[MESH] |Adult[MESH] |Aged[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |CD8-Positive T-Lymphocytes/enzymology/immunology[MESH] |COVID-19/*blood/*immunology[MESH] |Chemokine CCL2/blood[MESH] |Chemokine CXCL10/blood[MESH] |Chemokine CXCL9/blood[MESH] |Critical Illness[MESH] |Cytokine Release Syndrome/blood/immunology[MESH] |Dendritic Cells/immunology[MESH] |Female[MESH] |Granzymes/metabolism[MESH] |Humans[MESH] |Inflammation/*etiology[MESH] |Interleukin-10/blood[MESH] |Interleukin-6/blood[MESH] |Killer Cells, Natural/enzymology/immunology[MESH] |Male[MESH] |Membrane Glycoproteins/blood[MESH] |Middle Aged[MESH]Immunological and inflammatory profiles during acute and convalescent (epmc).pdf DeepDyve Pubget Overpricing