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10.1016/j.immuni.2021.04.009 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.04.009 33951417!8049468!33951417     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (5): 1066-1082.e5 Nephropedia Template TP {{tp|p=33951417|t=2021. CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity |pdf=|usr=}}{{33951417}} gab.com Text CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33951417 #FOAvip To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells. By using peptide-human leukocyte antigen (HLA) tetramers for direct ex vivo analysis, we characterized CD8(+) T cells specific for SARS-CoV-2 epitopes in COVID-19 patients and unexposed individuals. Unlike CD8(+) T cells directed toward subdominant epitopes (B7/N(257), A2/S(269), and A24/S(1,208)) CD8(+) T cells specific for the immunodominant B7/N(105) epitope were detected at high frequencies in pre-pandemic samples and at increased frequencies during acute COVID-19 and convalescence. SARS-CoV-2-specific CD8(+) T cells in pre-pandemic samples from children, adults, and elderly individuals predominantly displayed a naive phenotype, indicating a lack of previous cross-reactive exposures. T cell receptor (TCR) analyses revealed diverse TCRalphabeta repertoires and promiscuous alphabeta-TCR pairing within B7/N(105)(+)CD8(+) T cells. Our study demonstrates high naive precursor frequency and TCRalphabeta diversity within immunodominant B7/N(105)-specific CD8(+) T cells and provides insight into SARS-CoV-2-specific T cell origins and subsequent responses. Twit Text FOAVip CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33951417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33951417 #FOAvip English Wikipedia <ref>{{Cite pmid|33951417}}</ref> CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity #MMPMID33951417 Nguyen THO; Rowntree LC; Petersen J; Chua BY; Hensen L; Kedzierski L; van de Sandt CE; Chaurasia P; Tan HX; Habel JR; Zhang W; Allen LF; Earnest L; Mak KY; Juno JA; Wragg K; Mordant FL; Amanat F; Krammer F; Mifsud NA; Doolan DL; Flanagan KL; Sonda S; Kaur J; Wakim LM; Westall GP; James F; Mouhtouris E; Gordon CL; Holmes NE; Smibert OC; Trubiano JA; Cheng AC; Harcourt P; Clifton P; Crawford JC; Thomas PG; Wheatley AK; Kent SJ; Rossjohn J; Torresi J; Kedzierska K Immunity 2021[May]; 54 (5): 1066-1082.e5 PMID33951417show ga To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells. By using peptide-human leukocyte antigen (HLA) tetramers for direct ex vivo analysis, we characterized CD8(+) T cells specific for SARS-CoV-2 epitopes in COVID-19 patients and unexposed individuals. Unlike CD8(+) T cells directed toward subdominant epitopes (B7/N(257), A2/S(269), and A24/S(1,208)) CD8(+) T cells specific for the immunodominant B7/N(105) epitope were detected at high frequencies in pre-pandemic samples and at increased frequencies during acute COVID-19 and convalescence. SARS-CoV-2-specific CD8(+) T cells in pre-pandemic samples from children, adults, and elderly individuals predominantly displayed a naive phenotype, indicating a lack of previous cross-reactive exposures. T cell receptor (TCR) analyses revealed diverse TCRalphabeta repertoires and promiscuous alphabeta-TCR pairing within B7/N(105)(+)CD8(+) T cells. Our study demonstrates high naive precursor frequency and TCRalphabeta diversity within immunodominant B7/N(105)-specific CD8(+) T cells and provides insight into SARS-CoV-2-specific T cell origins and subsequent responses. |Adult[MESH] |Aged[MESH] |Amino Acid Motifs[MESH] |CD4-Positive T-Lymphocytes[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Child[MESH] |Convalescence[MESH] |Coronavirus Nucleocapsid Proteins/chemistry/*immunology[MESH] |Epitopes, T-Lymphocyte/chemistry/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunodominant Epitopes/chemistry/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Phenotype[MESH] |Phosphoproteins/chemistry/immunology[MESH] |Receptors, Antigen, T-Cell, alpha-beta/chemistry/genetics/immunology[MESH] |Receptors, Antigen, T-Cell/chemistry/genetics/*immunology[MESH] |SARS-CoV-2/*immunology[MESH]CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid (epmc).pdf DeepDyve Pubget Overpricing