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10.1126/science.abg5268 http://scihub22266oqcxt.onion/10.1126/science.abg5268 33947773!8224265!33947773     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 372 (6546): 1108-1112 Nephropedia Template TP {{tp|p=33947773|t=2021. Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes |pdf=|usr=}}{{33947773}} gab.com Text Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33947773 #FOAvip The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor binding domain (RBD). In one subject, just four IgG lineages accounted for 93.5% of the response, including an amino (N)-terminal domain (NTD)-directed antibody that was protective against lethal viral challenge. Genetic, structural, and functional characterization of a multidonor class of "public" antibodies revealed an NTD epitope that is recurrently mutated among emerging SARS-CoV-2 variants of concern. These data show that "public" NTD-directed and other non-RBD plasma antibodies are prevalent and have implications for SARS-CoV-2 protection and antibody escape. Twit Text FOAVip Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33947773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33947773 #FOAvip English Wikipedia <ref>{{Cite pmid|33947773}}</ref> Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes #MMPMID33947773 Voss WN; Hou YJ; Johnson NV; Delidakis G; Kim JE; Javanmardi K; Horton AP; Bartzoka F; Paresi CJ; Tanno Y; Chou CW; Abbasi SA; Pickens W; George K; Boutz DR; Towers DM; McDaniel JR; Billick D; Goike J; Rowe L; Batra D; Pohl J; Lee J; Gangappa S; Sambhara S; Gadush M; Wang N; Person MD; Iverson BL; Gollihar JD; Dye JM; Herbert AS; Finkelstein IJ; Baric RS; McLellan JS; Georgiou G; Lavinder JJ; Ippolito GC Science 2021[Jun]; 372 (6546): 1108-1112 PMID33947773show ga The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor binding domain (RBD). In one subject, just four IgG lineages accounted for 93.5% of the response, including an amino (N)-terminal domain (NTD)-directed antibody that was protective against lethal viral challenge. Genetic, structural, and functional characterization of a multidonor class of "public" antibodies revealed an NTD epitope that is recurrently mutated among emerging SARS-CoV-2 variants of concern. These data show that "public" NTD-directed and other non-RBD plasma antibodies are prevalent and have implications for SARS-CoV-2 protection and antibody escape. |Animals[MESH] |Antibodies, Monoclonal/blood/chemistry/immunology[MESH] |Antibodies, Neutralizing/blood/chemistry/*immunology[MESH] |Antibodies, Viral/blood/chemistry/*immunology[MESH] |Antibody Affinity[MESH] |COVID-19/*immunology/prevention & control[MESH] |Epitopes/immunology[MESH] |Humans[MESH] |Immune Evasion[MESH] |Immunoglobulin G/blood/chemistry/*immunology[MESH] |Immunoglobulin Heavy Chains/immunology[MESH] |Immunoglobulin Variable Region/immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mutation[MESH] |Protein Domains[MESH] |Proteomics[MESH] |SARS-CoV-2/genetics/*immunology[MESH]Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 no(epmc).pdf DeepDyve Pubget Overpricing