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10.1186/s12879-021-06108-5

http://scihub22266oqcxt.onion/10.1186/s12879-021-06108-5
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suck abstract from ncbi


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pmid33947347      BMC+Infect+Dis 2021 ; 21 (1): 410
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  • Salivary testing of COVID-19: evaluation of serological testing following positive salivary results #MMPMID33947347
  • Caulley L; Shaw J; Corsten M; Hua N; Angel JB; Poliquin G; Whelan J; Antonation K; Johnson-Obaseki S
  • BMC Infect Dis 2021[May]; 21 (1): 410 PMID33947347show ga
  • BACKGROUND: Salivary detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been proposed as an alternative to nasopharyngeal or oropharyngeal swab testing. Our group previously published a study demonstrating that both testing methods identified SARS-CoV-2 using polymerase chain reaction (PCR)-based detection methodology. We therefore conducted a follow-up study using antibody testing to evaluate the accuracy of saliva versus swabs for COVID-19 detection and the durability of antibody response. METHODS: Venous blood samples were collected from consenting participants and the presence of serum antibodies for SARS-CoV-2 was evaluated on a large, automated immunoassay platform by the Roche anti-SARS-CoV-2 qualitative assay (Roche Diagnostics, Laval Quebec). Individuals with a serum antibody cut-off index (COI) >/= 1.0 were considered positive. RESULTS: In asymptomatic and mildly symptomatic patients with a previously positive standard swab and/or saliva SARS-CoV-2 PCR-test, 42 demonstrated antibodies with 13 patients positive by swab alone, and 8 patients positive by saliva alone. CONCLUSIONS: Despite their status as 'current standard' for COVID-19 testing, these findings highlight limitations of PCR-based tests.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/analysis/blood[MESH]
  • |COVID-19 Nucleic Acid Testing/methods[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19/*immunology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Immunity, Humoral[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2/genetics/immunology[MESH]
  • |Saliva/*virology[MESH]


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