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10.3390/ijms22094726 http://scihub22266oqcxt.onion/10.3390/ijms22094726 33946935!8125486!33946935     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (9): ä Nephropedia Template TP {{tp|p=33946935|t=2021. Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils |pdf=|usr=}}{{33946935}} gab.com Text Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33946935 #FOAvip Interferons (IFNs) are induced by viruses and are the main regulators of the host antiviral response. They balance tissue tolerance and immune resistance against viral challenges. Like all cells in the human body, neutrophils possess the receptors for IFNs and contribute to antiviral host defense. To combat viruses, neutrophils utilize various mechanisms, such as viral sensing, neutrophil extracellular trap formation, and antigen presentation. These mechanisms have also been linked to tissue damage during viral infection and inflammation. In this review, we presented evidence that a complex cross-regulatory talk between IFNs and neutrophils initiates appropriate antiviral immune responses and regulates them to minimize tissue damage. We also explored recent exciting research elucidating the interactions between IFNs, neutrophils, and severe acute respiratory syndrome-coronavirus-2, as an example of neutrophil and IFN cross-regulatory talk. Dissecting the IFN-neutrophil paradigm is needed for well-balanced antiviral therapeutics and development of novel treatments against many major epidemic or pandemic viral infections, including the ongoing pandemic of the coronavirus disease that emerged in 2019. Twit Text FOAVip Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33946935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33946935 #FOAvip English Wikipedia <ref>{{Cite pmid|33946935}}</ref> Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils #MMPMID33946935 Stegelmeier AA; Darzianiazizi M; Hanada K; Sharif S; Wootton SK; Bridle BW; Karimi K Int J Mol Sci 2021[Apr]; 22 (9): ä PMID33946935show ga Interferons (IFNs) are induced by viruses and are the main regulators of the host antiviral response. They balance tissue tolerance and immune resistance against viral challenges. Like all cells in the human body, neutrophils possess the receptors for IFNs and contribute to antiviral host defense. To combat viruses, neutrophils utilize various mechanisms, such as viral sensing, neutrophil extracellular trap formation, and antigen presentation. These mechanisms have also been linked to tissue damage during viral infection and inflammation. In this review, we presented evidence that a complex cross-regulatory talk between IFNs and neutrophils initiates appropriate antiviral immune responses and regulates them to minimize tissue damage. We also explored recent exciting research elucidating the interactions between IFNs, neutrophils, and severe acute respiratory syndrome-coronavirus-2, as an example of neutrophil and IFN cross-regulatory talk. Dissecting the IFN-neutrophil paradigm is needed for well-balanced antiviral therapeutics and development of novel treatments against many major epidemic or pandemic viral infections, including the ongoing pandemic of the coronavirus disease that emerged in 2019. |Animals[MESH] |Antiviral Agents/immunology[MESH] |COVID-19/*immunology[MESH] |Extracellular Traps/immunology[MESH] |Humans[MESH] |Interferon Type I/*immunology[MESH] |Neutrophils/*immunology[MESH] |SARS-CoV-2/immunology[MESH] |Signal Transduction[MESH] |Virus Diseases/*immunology[MESH]Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neu(epmc).pdf DeepDyve Pubget Overpricing