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10.3390/molecules26092593

http://scihub22266oqcxt.onion/10.3390/molecules26092593
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33946802!8124269!33946802
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suck abstract from ncbi


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pmid33946802      Molecules 2021 ; 26 (9): ä
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  • Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus #MMPMID33946802
  • Terrier O; Dilly S; Pizzorno A; Chalupska D; Humpolickova J; Boura E; Berenbaum F; Quideau S; Lina B; Feve B; Adnet F; Sabbah M; Rosa-Calatrava M; Marechal V; Henri J; Slama-Schwok A
  • Molecules 2021[Apr]; 26 (9): ä PMID33946802show ga
  • There is an urgent need for specific antiviral treatments directed against SARS-CoV-2 to prevent the most severe forms of COVID-19. By drug repurposing, affordable therapeutics could be supplied worldwide in the present pandemic context. Targeting the nucleoprotein N of the SARS-CoV-2 coronavirus could be a strategy to impede viral replication and possibly other essential functions associated with viral N. The antiviral properties of naproxen, a non-steroidal anti-inflammatory drug (NSAID) that was previously demonstrated to be active against Influenza A virus, were evaluated against SARS-CoV-2. Intrinsic fluorescence spectroscopy, fluorescence anisotropy, and dynamic light scattering assays demonstrated naproxen binding to the nucleoprotein of SARS-Cov-2 as predicted by molecular modeling. Naproxen impeded recombinant N oligomerization and inhibited viral replication in infected cells. In VeroE6 cells and reconstituted human primary respiratory epithelium models of SARS-CoV-2 infection, naproxen specifically inhibited viral replication and protected the bronchial epithelia against SARS-CoV-2-induced damage. No inhibition of viral replication was observed with paracetamol or the COX-2 inhibitor celecoxib. Thus, among the NSAID tested, only naproxen combined antiviral and anti-inflammatory properties. Naproxen addition to the standard of care could be beneficial in a clinical setting, as tested in an ongoing clinical study.
  • |*COVID-19 Drug Treatment[MESH]
  • |Animals[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/*pharmacology[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |Cell Line[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Drug Repositioning[MESH]
  • |Humans[MESH]
  • |Molecular Docking Simulation[MESH]
  • |Naproxen/*pharmacology[MESH]
  • |Nucleoproteins/*antagonists & inhibitors/metabolism[MESH]
  • |SARS-CoV-2/*drug effects/physiology[MESH]
  • |Vero Cells[MESH]
  • |Viral Proteins/*antagonists & inhibitors/metabolism[MESH]


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