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10.3390/ijms22094794 http://scihub22266oqcxt.onion/10.3390/ijms22094794 33946479!8124482!33946479     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (9): ä Nephropedia Template TP {{tp|p=33946479|t=2021. Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients |pdf=|usr=}}{{33946479}} gab.com Text Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33946479 #FOAvip The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10), or critical (N = 26). A panel of 221 biomarkers was measured by targeted metabolomics in order to evaluate metabolic changes associated with subsequent disease severity. Our results show that obesity, respiratory rate, blood pressure, and oxygen saturation, as well as some analytical parameters and radiological findings, were all associated with disease severity. Additionally, ceramide metabolism, tryptophan degradation, and reductions in several metabolic reactions involving nicotinamide adenine nucleotide (NAD) at inclusion were significantly associated with respiratory severity and correlated with inflammation. In summary, assessment of the metabolomic profile of COVID-19 patients could assist in disease severity stratification and even in guiding clinical decisions. Twit Text FOAVip Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33946479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33946479 #FOAvip English Wikipedia <ref>{{Cite pmid|33946479}}</ref> Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients #MMPMID33946479 Marin-Corral J; Rodriguez-Morato J; Gomez-Gomez A; Pascual-Guardia S; Munoz-Bermudez R; Salazar-Degracia A; Perez-Teran P; Restrepo MI; Khymenets O; Haro N; Masclans JR; Pozo OJ Int J Mol Sci 2021[Apr]; 22 (9): ä PMID33946479show ga The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10), or critical (N = 26). A panel of 221 biomarkers was measured by targeted metabolomics in order to evaluate metabolic changes associated with subsequent disease severity. Our results show that obesity, respiratory rate, blood pressure, and oxygen saturation, as well as some analytical parameters and radiological findings, were all associated with disease severity. Additionally, ceramide metabolism, tryptophan degradation, and reductions in several metabolic reactions involving nicotinamide adenine nucleotide (NAD) at inclusion were significantly associated with respiratory severity and correlated with inflammation. In summary, assessment of the metabolomic profile of COVID-19 patients could assist in disease severity stratification and even in guiding clinical decisions. |*Metabolome[MESH] |Adult[MESH] |Aged[MESH] |Biomarkers/blood/metabolism[MESH] |COVID-19/blood/*metabolism/pathology[MESH] |Ceramides/blood/metabolism[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Kynurenine/blood/metabolism[MESH] |Male[MESH] |Metabolomics[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |SARS-CoV-2/*physiology[MESH] |Severity of Illness Index[MESH]Metabolic Signatures Associated with Severity in Hospitalized COVID-19(epmc).pdf DeepDyve Pubget Overpricing