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10.3390/ijms22094776 http://scihub22266oqcxt.onion/10.3390/ijms22094776 33946341!8125008!33946341     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33946341&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33946341.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2021 ; 22 (9): ä Nephropedia Template TP {{tp|p=33946341|t=2021. Proteomics: A Tool to Study Platelet Function |pdf=|usr=}}{{33946341}} gab.com Text Proteomics: A Tool to Study Platelet Function JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33946341 #FOAvip Platelets are components of the blood that are highly reactive, and they quickly respond to multiple physiological and pathophysiological processes. In the last decade, it became clear that platelets are the key components of circulation, linking hemostasis, innate, and acquired immunity. Protein composition, localization, and activity are crucial for platelet function and regulation. The current state of mass spectrometry-based proteomics has tremendous potential to identify and quantify thousands of proteins from a minimal amount of material, unravel multiple post-translational modifications, and monitor platelet activity during drug treatments. This review focuses on the role of proteomics in understanding the molecular basics of the classical and newly emerging functions of platelets. including the recently described role of platelets in immunology and the development of COVID-19.The state-of-the-art proteomic technologies and their application in studying platelet biogenesis, signaling, and storage are described, and the potential of newly appeared trapped ion mobility spectrometry (TIMS) is highlighted. Additionally, implementing proteomic methods in platelet transfusion medicine, and as a diagnostic and prognostic tool, is discussed. Twit Text FOAVip Proteomics: A Tool to Study Platelet Function ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33946341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33946341 #FOAvip English Wikipedia <ref>{{Cite pmid|33946341}}</ref> Proteomics: A Tool to Study Platelet Function #MMPMID33946341 Shevchuk O; Begonja AJ; Gambaryan S; Totzeck M; Rassaf T; Huber TB; Greinacher A; Renne T; Sickmann A Int J Mol Sci 2021[Apr]; 22 (9): ä PMID33946341show ga Platelets are components of the blood that are highly reactive, and they quickly respond to multiple physiological and pathophysiological processes. In the last decade, it became clear that platelets are the key components of circulation, linking hemostasis, innate, and acquired immunity. Protein composition, localization, and activity are crucial for platelet function and regulation. The current state of mass spectrometry-based proteomics has tremendous potential to identify and quantify thousands of proteins from a minimal amount of material, unravel multiple post-translational modifications, and monitor platelet activity during drug treatments. This review focuses on the role of proteomics in understanding the molecular basics of the classical and newly emerging functions of platelets. including the recently described role of platelets in immunology and the development of COVID-19.The state-of-the-art proteomic technologies and their application in studying platelet biogenesis, signaling, and storage are described, and the potential of newly appeared trapped ion mobility spectrometry (TIMS) is highlighted. Additionally, implementing proteomic methods in platelet transfusion medicine, and as a diagnostic and prognostic tool, is discussed. |Animals[MESH] |Blood Platelets/cytology/immunology/*metabolism[MESH] |COVID-19/immunology/metabolism[MESH] |Humans[MESH] |Mass Spectrometry/*methods[MESH] |Platelet Function Tests/*methods[MESH] |Platelet Transfusion[MESH] |Protein Processing, Post-Translational[MESH] |Proteomics/*methods[MESH] |Signal Transduction[MESH]Proteomics: A Tool to Study Platelet Function (epmc).pdf DeepDyve Pubget Overpricing