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10.1016/j.immuni.2021.04.006 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.04.006 33945786!8043652!33945786     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (5): 1055-1065.e5 Nephropedia Template TP {{tp|p=33945786|t=2021. CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses |pdf=|usr=}}{{33945786}} gab.com Text CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33945786 #FOAvip Efforts are being made worldwide to understand the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, including the impact of T cell immunity and cross-recognition with seasonal coronaviruses. Screening of SARS-CoV-2 peptide pools revealed that the nucleocapsid (N) protein induced an immunodominant response in HLA-B7(+) COVID-19-recovered individuals that was also detectable in unexposed donors. A single N-encoded epitope that was highly conserved across circulating coronaviruses drove this immunodominant response. In vitro peptide stimulation and crystal structure analyses revealed T cell-mediated cross-reactivity toward circulating OC43 and HKU-1 betacoronaviruses but not 229E or NL63 alphacoronaviruses because of different peptide conformations. T cell receptor (TCR) sequencing indicated that cross-reactivity was driven by private TCR repertoires with a bias for TRBV27 and a long CDR3beta loop. Our findings demonstrate the basis of selective T cell cross-reactivity for an immunodominant SARS-CoV-2 epitope and its homologs from seasonal coronaviruses, suggesting long-lasting protective immunity. Twit Text FOAVip CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33945786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33945786 #FOAvip English Wikipedia <ref>{{Cite pmid|33945786}}</ref> CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses #MMPMID33945786 Lineburg KE; Grant EJ; Swaminathan S; Chatzileontiadou DSM; Szeto C; Sloane H; Panikkar A; Raju J; Crooks P; Rehan S; Nguyen AT; Lekieffre L; Neller MA; Tong ZWM; Jayasinghe D; Chew KY; Lobos CA; Halim H; Burrows JM; Riboldi-Tunnicliffe A; Chen W; D'Orsogna L; Khanna R; Short KR; Smith C; Gras S Immunity 2021[May]; 54 (5): 1055-1065.e5 PMID33945786show ga Efforts are being made worldwide to understand the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, including the impact of T cell immunity and cross-recognition with seasonal coronaviruses. Screening of SARS-CoV-2 peptide pools revealed that the nucleocapsid (N) protein induced an immunodominant response in HLA-B7(+) COVID-19-recovered individuals that was also detectable in unexposed donors. A single N-encoded epitope that was highly conserved across circulating coronaviruses drove this immunodominant response. In vitro peptide stimulation and crystal structure analyses revealed T cell-mediated cross-reactivity toward circulating OC43 and HKU-1 betacoronaviruses but not 229E or NL63 alphacoronaviruses because of different peptide conformations. T cell receptor (TCR) sequencing indicated that cross-reactivity was driven by private TCR repertoires with a bias for TRBV27 and a long CDR3beta loop. Our findings demonstrate the basis of selective T cell cross-reactivity for an immunodominant SARS-CoV-2 epitope and its homologs from seasonal coronaviruses, suggesting long-lasting protective immunity. |Amino Acid Sequence[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Coronavirus Nucleocapsid Proteins/chemistry/*immunology[MESH] |Coronavirus/classification/immunology[MESH] |Cross Reactions[MESH] |Epitopes, T-Lymphocyte/chemistry/immunology[MESH] |HLA-B7 Antigen/chemistry/genetics/immunology[MESH] |Humans[MESH] |Immunodominant Epitopes/chemistry/*immunology[MESH] |Immunologic Memory[MESH] |Models, Molecular[MESH] |Peptides/chemistry/immunology[MESH] |Receptors, Antigen, T-Cell/chemistry/genetics/immunology[MESH]CD8(+) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid (epmc).pdf DeepDyve Pubget Overpricing