Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/jmv.27059 http://scihub22266oqcxt.onion/10.1002/jmv.27059 33945634!8242749!33945634     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (9): 5416-5424 Nephropedia Template TP {{tp|p=33945634|t=2021. Determinants of IgG antibodies kinetics after severe and critical COVID-19 |pdf=|usr=}}{{33945634}} gab.com Text Determinants of IgG antibodies kinetics after severe and critical COVID-19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33945634 #FOAvip The kinetics of IgG antibodies after coronavirus disease 2019 (COVID-19) remain poorly understood. We investigated factors influencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibody levels and time to seronegativation during the follow-up of severe and critically ill patients. We retrospectively reviewed serological evaluations drawn during the follow-up of severe or critical laboratory-proven COVID-19 patients hospitalized at a large academic hospital. Specific IgG titers were measured using a chemiluminescent assay targeting anti-spike and anti-nucleocapsid protein IgG. The influence of time, demographic factors, clinical and paraclinical characteristics, and COVID-19 therapeutics on IgG levels were assessed through linear regression using a mixed-effect model, and delay until IgG negativation through a Weibull regression model. The cohort included 116 patients with a total of 154 IgG measurements drawn at a median of 79 days after diagnosis. IgG antibodies were increased with age (p = 0.005) and decreased significantly over time (p = 0.0002). Using elapsed time and age as covariates, we demonstrated higher IgG levels in patients with a higher body mass index (BMI) (p = 0.0026) and lower IgG levels in immunocompromised patients (p = 0.032). A high BMI was further found to delay and immunodeficiency to hasten significantly seronegativation, whereas no significant effect was observed with corticosteroids. These data highlight the waning over time of IgG antibodies after severe or critical COVID-19. Age, BMI, and immunosuppression also appear to influence the IgG kinetics, while short-term corticotherapy does not. Those data improve the understanding of SARS-CoV-2 serology while further research should determine the determinants of long-term seroprotection. Twit Text FOAVip Determinants of IgG antibodies kinetics after severe and critical COVID-19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33945634 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33945634 #FOAvip English Wikipedia <ref>{{Cite pmid|33945634}}</ref> Determinants of IgG antibodies kinetics after severe and critical COVID-19 #MMPMID33945634 De Greef J; Scohy A; Zech F; Aboubakar F; Pilette C; Gerard L; Pothen L; Yildiz H; Belkhir L; Yombi JC J Med Virol 2021[Sep]; 93 (9): 5416-5424 PMID33945634show ga The kinetics of IgG antibodies after coronavirus disease 2019 (COVID-19) remain poorly understood. We investigated factors influencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibody levels and time to seronegativation during the follow-up of severe and critically ill patients. We retrospectively reviewed serological evaluations drawn during the follow-up of severe or critical laboratory-proven COVID-19 patients hospitalized at a large academic hospital. Specific IgG titers were measured using a chemiluminescent assay targeting anti-spike and anti-nucleocapsid protein IgG. The influence of time, demographic factors, clinical and paraclinical characteristics, and COVID-19 therapeutics on IgG levels were assessed through linear regression using a mixed-effect model, and delay until IgG negativation through a Weibull regression model. The cohort included 116 patients with a total of 154 IgG measurements drawn at a median of 79 days after diagnosis. IgG antibodies were increased with age (p = 0.005) and decreased significantly over time (p = 0.0002). Using elapsed time and age as covariates, we demonstrated higher IgG levels in patients with a higher body mass index (BMI) (p = 0.0026) and lower IgG levels in immunocompromised patients (p = 0.032). A high BMI was further found to delay and immunodeficiency to hasten significantly seronegativation, whereas no significant effect was observed with corticosteroids. These data highlight the waning over time of IgG antibodies after severe or critical COVID-19. Age, BMI, and immunosuppression also appear to influence the IgG kinetics, while short-term corticotherapy does not. Those data improve the understanding of SARS-CoV-2 serology while further research should determine the determinants of long-term seroprotection. |*Immunocompromised Host[MESH] |Adrenal Cortex Hormones/therapeutic use[MESH] |Aged[MESH] |Antibodies, Viral/*blood[MESH] |Body Mass Index[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19 Serological Testing[MESH] |COVID-19/blood/diagnosis/*immunology[MESH] |Convalescence[MESH] |Female[MESH] |Humans[MESH] |Hydroxychloroquine/therapeutic use[MESH] |Immunoglobulin G/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Respiratory Insufficiency/blood/diagnosis/drug therapy/*immunology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/*immunology[MESH] |Sensitivity and Specificity[MESH] |Severity of Illness Index[MESH]Determinants of IgG antibodies kinetics after severe and critical COVI(epmc).pdf DeepDyve Pubget Overpricing