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10.1007/s11427-020-1921-5 http://scihub22266oqcxt.onion/10.1007/s11427-020-1921-5 33945070!8093132!33945070     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+China+Life+Sci 2021 ; 64 (12): 2129-2143 Nephropedia Template TP {{tp|p=33945070|t=2021. Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China |pdf=|usr=}}{{33945070}} gab.com Text Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China JO: Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33945070 #FOAvip Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in coronavirus disease 2019 (COVID-19) patients have been reported. However, the clinical outcome and pathogenesis remain unclear. In this study, we recruited 43 laboratory-confirmed COVID-19 patients. We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients (P<0.05). The average viral shedding time in severe/critical patients was more than 50 days, and up to 100 days in some patients, after symptom onset. However, chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive, but specific antibodies appeared. Furthermore, the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred (P<0.01 and FDR<0.01) and increased when G227A occurred (P<0.05 and FDR<0.05). High IL1R1, IL1R2, and TNFRSF21 expression in the host positively correlated with viral shedding time (P<0.05 and false discovery rate <0.05). Prolonged viral RNA shedding often occurs but may not increase disease damage. Prolonged viral RNA shedding is associated with viral mutations and host factors. Twit Text FOAVip Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China ????Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33945070 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33945070 #FOAvip English Wikipedia <ref>{{Cite pmid|33945070}}</ref> Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China #MMPMID33945070 Li Z; Li Y; Sun R; Li S; Chen L; Zhan Y; Xie M; Yang J; Wang Y; Zhu A; Gu G; Yu L; Li S; Liu T; Chen Z; Jian W; Jiang Q; Su X; Gu W; Chen L; Cheng J; Zhao J; Lu W; Zheng J; Li S; Zhong N; Ye F Sci China Life Sci 2021[Dec]; 64 (12): 2129-2143 PMID33945070show ga Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in coronavirus disease 2019 (COVID-19) patients have been reported. However, the clinical outcome and pathogenesis remain unclear. In this study, we recruited 43 laboratory-confirmed COVID-19 patients. We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients (P<0.05). The average viral shedding time in severe/critical patients was more than 50 days, and up to 100 days in some patients, after symptom onset. However, chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive, but specific antibodies appeared. Furthermore, the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred (P<0.01 and FDR<0.01) and increased when G227A occurred (P<0.05 and FDR<0.05). High IL1R1, IL1R2, and TNFRSF21 expression in the host positively correlated with viral shedding time (P<0.05 and false discovery rate <0.05). Prolonged viral RNA shedding often occurs but may not increase disease damage. Prolonged viral RNA shedding is associated with viral mutations and host factors. |Adult[MESH] |Antibodies, Neutralizing/blood[MESH] |Antibodies, Viral/blood[MESH] |COVID-19/epidemiology/pathology/*virology[MESH] |China/epidemiology[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Genome, Viral/genetics[MESH] |Hospitalization[MESH] |Humans[MESH] |Longitudinal Studies[MESH] |Lung/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Mutation[MESH] |RNA, Viral/genetics/metabolism[MESH] |SARS-CoV-2/genetics/isolation & purification/*pathogenicity/physiology[MESH] |Time Factors[MESH] |Virus Replication[MESH]Longitudinal virological changes and underlying pathogenesis in hospit(epmc).pdf DeepDyve Pubget Overpricing