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10.1016/j.ensci.2021.100344

http://scihub22266oqcxt.onion/10.1016/j.ensci.2021.100344
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suck abstract from ncbi


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pmid33937536      eNeurologicalSci 2021 ; 23 (ä): 100344
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  • Familial hypercholesterolemia and statins in the COVID-19 era: Mitigating the risk of ischemic stroke #MMPMID33937536
  • Vuorio A; Kaste M; Kovanen PT
  • eNeurologicalSci 2021[Jun]; 23 (ä): 100344 PMID33937536show ga
  • There is a continuing need for research about the underlying mechanisms behind ischemic strokes in COVID-19 patients. Pre-existing endothelial dysfunction, especially if it is accompanied by a viral infection of the endothelial cells may present an important mechanism behind the immunothrombotic/thromboembolic complications of the COVID-19 illness. Here we emphasize that pharmacotherapy with statins could partly counteract such pathophysiological scenarios. Accordingly, using familial hypercholesterolemia (FH) as a pertinent example of a lifelong endothelial dysfunction, we aim to make the clinicians and consulting neurologists aware of statins as a possible adjuvant therapy in the context of an increased risk of ischemic stroke in patients with COVID-19. Based on recent clinical evidence, there is a need to encourage clinicians and consulting neurologists to continue or initiate effective statin treatment to prevent an ischemic stroke, particularly when they encounter a hypercholesterolemic COVID-19 patient with FH.
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