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10.1016/j.csbj.2021.04.003 http://scihub22266oqcxt.onion/10.1016/j.csbj.2021.04.003 33936565!8064971!33936565     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Struct+Biotechnol+J 2021 ; 19 (ä): 2246-2255 Nephropedia Template TP {{tp|p=33936565|t=2021. Targeting protein-protein interaction interfaces in COVID-19 drug discovery |pdf=|usr=}}{{33936565}} gab.com Text Targeting protein-protein interaction interfaces in COVID-19 drug discovery JO: Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=33936565 #FOAvip To date, the COVID-19 pandemic has claimed over 1 million human lives, infected another 50 million individuals and wreaked havoc on the global economy. The crisis has spurred the ongoing development of drugs targeting its etiological agent, the SARS-CoV-2. Targeting relevant protein-protein interaction interfaces (PPIIs) is a viable paradigm for the design of antiviral drugs and enriches the targetable chemical space by providing alternative targets for drug discovery. In this review, we will provide a comprehensive overview of the theory, methods and applications of PPII-targeted drug development towards COVID-19 based on recent literature. We will also highlight novel developments, such as the successful use of non-native protein-protein interactions as targets for antiviral drug screening. We hope that this review may serve as an entry point for those interested in applying PPIIs towards COVID-19 drug discovery and speed up drug development against the pandemic. Twit Text FOAVip Targeting protein-protein interaction interfaces in COVID-19 drug discovery ????Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=33936565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33936565 #FOAvip English Wikipedia <ref>{{Cite pmid|33936565}}</ref> Targeting protein-protein interaction interfaces in COVID-19 drug discovery #MMPMID33936565 Chang CK; Lin SM; Satange R; Lin SC; Sun SC; Wu HY; Kehn-Hall K; Hou MH Comput Struct Biotechnol J 2021[]; 19 (ä): 2246-2255 PMID33936565show ga To date, the COVID-19 pandemic has claimed over 1 million human lives, infected another 50 million individuals and wreaked havoc on the global economy. The crisis has spurred the ongoing development of drugs targeting its etiological agent, the SARS-CoV-2. Targeting relevant protein-protein interaction interfaces (PPIIs) is a viable paradigm for the design of antiviral drugs and enriches the targetable chemical space by providing alternative targets for drug discovery. In this review, we will provide a comprehensive overview of the theory, methods and applications of PPII-targeted drug development towards COVID-19 based on recent literature. We will also highlight novel developments, such as the successful use of non-native protein-protein interactions as targets for antiviral drug screening. We hope that this review may serve as an entry point for those interested in applying PPIIs towards COVID-19 drug discovery and speed up drug development against the pandemic. äTargeting protein-protein interaction interfaces in COVID-19 drug disc(epmc).pdf DeepDyve Pubget Overpricing