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10.1016/j.micpath.2021.104930

http://scihub22266oqcxt.onion/10.1016/j.micpath.2021.104930
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33933603!8084285!33933603
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suck abstract from ncbi


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pmid33933603      Microb+Pathog 2021 ; 155 (ä): 104930
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  • Promising role of defensins peptides as therapeutics to combat against viral infection #MMPMID33933603
  • Solanki SS; Singh P; Kashyap P; Sansi MS; Ali SA
  • Microb Pathog 2021[Jun]; 155 (ä): 104930 PMID33933603show ga
  • Antimicrobial peptides (AMPs) are ubiquitously present small peptides, which play a critical function in the innate immune system. The defensin class of AMPs represented an evolutionarily ancient family containing cationic cysteine residue and frequently expressed in epithelial or neutrophils cells. It plays myriad functions in host innate immune responses against various infection. Defensin has a broad spectrum of antimicrobial activities, including anti-bacteria, anti-viruses (AVPs), anti-fungi, anti-cancers, and also overcoming bacterial drug resistance. In this review, we compiled the progress on defensin, particularly incorporating the mechanism of action, their application as an antiviral agent, prospects in different areas, and limitations to be solved as an antiviral peptide. Defensins were explored, in particular, their capacity to stimulate innate and adaptive immunity by trigging as anti-coronavirus (COVID-19) peptides. The present review summarised its immunomodulatory and immunoenhancing properties and predominantly focused on its promising therapeutic adjuvant choices for combat against viral infection.
  • |*COVID-19[MESH]
  • |*Virus Diseases/drug therapy[MESH]
  • |Defensins[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Peptides[MESH]


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