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10.1016/j.celrep.2021.109109 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109109 33932326!8064889!33932326     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33932326&cmd=llinks): Failed to open stream: HTTP request failed! 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Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2 |pdf=|usr=}}{{33932326}} gab.com Text Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2 JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33932326 #FOAvip It is unclear whether individuals with enormous diversity in B cell receptor repertoires are consistently able to mount effective antibody responses against SARS-CoV-2. We analyzed antibody responses in a cohort of 55 convalescent patients and isolated 54 potent neutralizing monoclonal antibodies (mAbs). While most of the mAbs target the angiotensin-converting enzyme 2 (ACE2) binding surface on the receptor binding domain (RBD) of SARS-CoV-2 spike protein, mAb 47D1 binds only to one side of the receptor binding surface on the RBD. Neutralization by 47D1 is achieved independent of interfering RBD-ACE2 binding. A crystal structure of the mAb-RBD complex shows that the IF motif at the tip of 47D1 CDR H2 interacts with a hydrophobic pocket in the RBD. Diverse immunoglobulin gene usage and convergent epitope targeting characterize neutralizing antibody responses to SARS-CoV-2, suggesting that vaccines that effectively present the receptor binding site on the RBD will likely elicit neutralizing antibody responses in a large fraction of the population. Twit Text FOAVip Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2 ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33932326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33932326 #FOAvip English Wikipedia <ref>{{Cite pmid|33932326}}</ref> Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2 #MMPMID33932326 Zhou X; Ma F; Xie J; Yuan M; Li Y; Shaabani N; Zhao F; Huang D; Wu NC; Lee CD; Liu H; Li J; Chen Z; Hong Y; Liu WH; Xiao N; Burton DR; Tu H; Li H; Chen X; Teijaro JR; Wilson IA; Xiao C; Huang Z Cell Rep 2021[May]; 35 (6): 109109 PMID33932326show ga It is unclear whether individuals with enormous diversity in B cell receptor repertoires are consistently able to mount effective antibody responses against SARS-CoV-2. We analyzed antibody responses in a cohort of 55 convalescent patients and isolated 54 potent neutralizing monoclonal antibodies (mAbs). While most of the mAbs target the angiotensin-converting enzyme 2 (ACE2) binding surface on the receptor binding domain (RBD) of SARS-CoV-2 spike protein, mAb 47D1 binds only to one side of the receptor binding surface on the RBD. Neutralization by 47D1 is achieved independent of interfering RBD-ACE2 binding. A crystal structure of the mAb-RBD complex shows that the IF motif at the tip of 47D1 CDR H2 interacts with a hydrophobic pocket in the RBD. Diverse immunoglobulin gene usage and convergent epitope targeting characterize neutralizing antibody responses to SARS-CoV-2, suggesting that vaccines that effectively present the receptor binding site on the RBD will likely elicit neutralizing antibody responses in a large fraction of the population. |Adult[MESH] |Antibodies, Monoclonal/immunology[MESH] |Antibodies, Neutralizing/*genetics/immunology[MESH] |Antibodies, Viral/immunology[MESH] |Binding Sites/immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*genetics/immunology/therapy[MESH] |Epitopes/genetics/immunology[MESH] |Female[MESH] |Genes, Immunoglobulin/genetics[MESH] |Genetic Variation/genetics[MESH] |Humans[MESH] |Immunization, Passive/methods[MESH] |Immunoglobulins/*genetics/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Protein Binding/immunology[MESH] |Protein Domains/genetics[MESH] |Receptors, Virus/immunology/metabolism[MESH]Diverse immunoglobulin gene usage and convergent epitope targeting in (epmc).pdf DeepDyve Pubget Overpricing