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10.1016/j.ijid.2021.04.072

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.04.072
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suck abstract from ncbi


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pmid33930540      Int+J+Infect+Dis 2021 ; 107 (ä): 215-218
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  • Comparative diagnostic performance of rapid antigen detection tests for COVID-19 in a hospital setting #MMPMID33930540
  • Bruzzone B; De Pace V; Caligiuri P; Ricucci V; Guarona G; Pennati BM; Boccotti S; Orsi A; Domnich A; Da Rin G; Icardi G
  • Int J Infect Dis 2021[Jun]; 107 (ä): 215-218 PMID33930540show ga
  • BACKGROUND: The availability of accurate and rapid diagnostic tools for COVID-19 is essential for tackling the ongoing pandemic. Our study aimed to quantify the performance of available antigen-detecting rapid diagnostic tests (Ag-RDTs) in a real-world hospital setting. METHODS: In this retrospective analysis, the diagnostic performance of 7 Ag-RDTs was compared with real-time reverse transcription quantitative polymerase chain reaction assay in terms of sensitivity, specificity and expected predictive values. RESULTS: A total of 321 matched Ag-RDTreal-time reverse transcription quantitative polymerase chain reaction samples were analyzed retrospectively. The overall sensitivity and specificity of the Ag-RDTs was 78.7% and 100%, respectively. However, a wide range of sensitivity estimates by brand (66.0%-93.8%) and cycle threshold (Ct) cut-off values (Ct <25: 96.2%; Ct 30-35: 31.1%) was observed. The optimal Ct cut-off value that maximized sensitivity was 29. CONCLUSIONS: The routine use of Ag-RDTs may be convenient in moderate-to-high intensity settings when high volumes of specimens are tested every day. However, the diagnostic performance of the commercially available tests may differ substantially.
  • |Antigens, Viral/*analysis[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Hospitals[MESH]
  • |Humans[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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