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10.1021/acsami.1c02755 http://scihub22266oqcxt.onion/10.1021/acsami.1c02755 33930273!ä!33930273 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Appl+Mater+Interfaces 2021 ; 13 (18): 20995-21006 Nephropedia Template TP {{tp|p=33930273|t=2021. Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment |pdf=|usr=}}{{33930273}} gab.com Text Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment JO: ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=33930273 #FOAvip COVID-19 has been diffusely pandemic around the world, characterized by massive morbidity and mortality. One of the remarkable threats associated with mortality may be the uncontrolled inflammatory processes, which were induced by SARS-CoV-2 in infected patients. As there are no specific drugs, exploiting safe and effective treatment strategies is an instant requirement to dwindle viral damage and relieve extreme inflammation simultaneously. Here, highly biocompatible glycyrrhizic acid (GA) nanoparticles (GANPs) were synthesized based on GA. In vitro investigations revealed that GANPs inhibit the proliferation of the murine coronavirus MHV-A59 and reduce proinflammatory cytokine production caused by MHV-A59 or the N protein of SARS-CoV-2. In an MHV-A59-induced surrogate mouse model of COVID-19, GANPs specifically target areas with severe inflammation, such as the lungs, which appeared to improve the accumulation of GANPs and enhance the effectiveness of the treatment. Further, GANPs also exert antiviral and anti-inflammatory effects, relieving organ damage and conferring a significant survival advantage to infected mice. Such a novel therapeutic agent can be readily manufactured into feasible treatment for COVID-19. Twit Text FOAVip Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment ????ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=33930273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33930273 #FOAvip English Wikipedia <ref>{{Cite pmid|33930273}}</ref> Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment #MMPMID33930273 Zhao Z; Xiao Y; Xu L; Liu Y; Jiang G; Wang W; Li B; Zhu T; Tan Q; Tang L; Zhou H; Huang X; Shan H ACS Appl Mater Interfaces 2021[May]; 13 (18): 20995-21006 PMID33930273show ga COVID-19 has been diffusely pandemic around the world, characterized by massive morbidity and mortality. One of the remarkable threats associated with mortality may be the uncontrolled inflammatory processes, which were induced by SARS-CoV-2 in infected patients. As there are no specific drugs, exploiting safe and effective treatment strategies is an instant requirement to dwindle viral damage and relieve extreme inflammation simultaneously. Here, highly biocompatible glycyrrhizic acid (GA) nanoparticles (GANPs) were synthesized based on GA. In vitro investigations revealed that GANPs inhibit the proliferation of the murine coronavirus MHV-A59 and reduce proinflammatory cytokine production caused by MHV-A59 or the N protein of SARS-CoV-2. In an MHV-A59-induced surrogate mouse model of COVID-19, GANPs specifically target areas with severe inflammation, such as the lungs, which appeared to improve the accumulation of GANPs and enhance the effectiveness of the treatment. Further, GANPs also exert antiviral and anti-inflammatory effects, relieving organ damage and conferring a significant survival advantage to infected mice. Such a novel therapeutic agent can be readily manufactured into feasible treatment for COVID-19. |Animals[MESH] |Anti-Inflammatory Agents/chemistry/*therapeutic use[MESH] |Antioxidants/chemistry/therapeutic use[MESH] |Antiviral Agents/chemistry/*therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Nucleocapsid Proteins/pharmacology[MESH] |Cytokines/metabolism[MESH] |Female[MESH] |Glycyrrhizic Acid/chemistry/*therapeutic use[MESH] |Humans[MESH] |Inflammation/*drug therapy[MESH] |Liver/pathology[MESH] |Lung/pathology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Murine hepatitis virus/drug effects[MESH] |Nanoparticles/chemistry/*therapeutic use[MESH] |Phosphoproteins/pharmacology[MESH] |RAW 264.7 Cells[MESH] |SARS-CoV-2/chemistry[MESH] |THP-1 Cells[MESH] |Viral Load/drug effects[MESH] |Virus Diseases/*drug therapy/pathology[MESH]Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Age(epmc).pdf DeepDyve Pubget Overpricing