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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Gynaecol+Obstet 2021 ; 154 (2): 212-219 Nephropedia Template TP
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Maternal death related to COVID-19: A systematic review and meta-analysis focused on maternal co-morbidities and clinical characteristics #MMPMID33930185
La Verde M; Riemma G; Torella M; Cianci S; Savoia F; Licciardi F; Scida S; Morlando M; Colacurci N; De Franciscis P
Int J Gynaecol Obstet 2021[Aug]; 154 (2): 212-219 PMID33930185show ga
BACKGROUND: Besides reducing the quality of obstetric care, the direct impact of COVID-19 on pregnancy and postpartum is uncertain. OBJECTIVE: To evaluate the characteristics of pregnant women who died due to COVID-19. SEARCH STRATEGY: Cochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021. SELECTION CRITERIA: Studies that compared deceased and survived pregnant women with COVID-19. DATA COLLECTION AND ANALYSIS: Relevant data were extracted and tabulated. The primary outcome was maternal co-morbidity. MAIN RESULTS: Thirteen studies with 154 deceased patients were included. Obesity doubled the risk of death (relative risk [RR] 2.48, 95% confidence interval [CI] 1.41-4.36, I(2) = 0%). No differences were found for gestational diabetes (RR 5.71; 95% CI 0.77-42.44, I(2) = 94%) or asthma (RR 2.05, 95% CI 0.81-5.15, I(2) = 0%). Overall, at least one severe co-morbidity showed a twofold increased risk of death (RR 2.26, 95% CI 1.77-2.89, I(2) = 76%). Admission to intensive care was related to a fivefold increased risk of death (RR 5.09, 95% CI 2.00-12.98, I(2) = 56%), with no difference in need for respiratory support (RR 0.53, 95% CI 0.23-1.48, I(2) = 95%) or mechanical ventilation (RR 4.34, 95% CI 0.96-19.60, I(2) = 58%). CONCLUSION: COVID-19 with at least one co-morbidity increases risk of intensive care and mortality.