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10.1093/labmed/lmab011

http://scihub22266oqcxt.onion/10.1093/labmed/lmab011
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33929022!8135851!33929022
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suck abstract from ncbi


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pmid33929022      Lab+Med 2021 ; 52 (5): e137-e146
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  • Cross-Institutional Evaluation of the Abbott ARCHITECT SARS-CoV-2 IgG Immunoassay #MMPMID33929022
  • Wiencek JR; Bachmann LM; Dinwiddie K; Miller GW; Bazydlo LAL
  • Lab Med 2021[Sep]; 52 (5): e137-e146 PMID33929022show ga
  • OBJECTIVE: To describe a cross-institutional approach to verify the Abbott ARCHITECT SARS-CoV-2 antibody assay and to document the kinetics of the serological response. METHODS: We conducted analytical performance evaluation studies using the Abbott ARCHITECT SARS-CoV-2 antibody assay on 5 Abbott ARCHITECT i2000 automated analyzers at 2 academic medical centers. RESULTS: Within-run and between-run coefficients of variance (CVs) for the antibody assay did not exceed 5.6% and 8.6%, respectively, for each institution. Quantitative and qualitative results agreed for lithium heparin plasma, EDTA-plasma and serum specimen types. Results for all SARS-CoV-2 IgG-positive and -negative specimens were concordant among analyzers except for 1 specimen at 1 institution. Qualitative and quantitative agreement was observed for specimens exchanged between institutions. All patients had detectable antibodies by day 10 from symptom onset and maintained seropositivity throughout specimen procurement. CONCLUSIONS: The analytical performance characteristics of the Abbott ARCHITECT SARS-CoV-2 antibody assay within and between 2 academic medical center clinical laboratories were acceptable for widespread clinical-laboratory use.
  • |Academic Medical Centers[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19 Serological Testing/*standards[MESH]
  • |COVID-19/blood/*diagnosis/immunology/virology[MESH]
  • |Humans[MESH]
  • |Immunoassay/*standards[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Observer Variation[MESH]
  • |Reproducibility of Results[MESH]
  • |SARS-CoV-2/*immunology/pathogenicity[MESH]
  • |Sensitivity and Specificity[MESH]


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