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10.1017/S0950268821001060 http://scihub22266oqcxt.onion/10.1017/S0950268821001060 33928885!8134885!33928885     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33928885&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epidemiol+Infect 2021 ; 149 (ä): e110 Nephropedia Template TP {{tp|p=33928885|t=2021. SARS-CoV-2 mutations: the biological trackway towards viral fitness |pdf=|usr=}}{{33928885}} gab.com Text SARS-CoV-2 mutations: the biological trackway towards viral fitness JO: Epidemiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33928885 #FOAvip The outbreak of pneumonia-like respiratory disorder at China and its rapid transmission world-wide resulted in public health emergency, which brought lineage B betacoronaviridae SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) into spotlight. The fairly high mutation rate, frequent recombination and interspecies transmission in betacoronaviridae are largely responsible for their temporal changes in infectivity and virulence. Investigation of global SARS-CoV-2 genotypes revealed considerable mutations in structural, non-structural, accessory proteins as well as untranslated regions. Among the various types of mutations, single-nucleotide substitutions are the predominant ones. In addition, insertion, deletion and frame-shift mutations are also reported, albeit at a lower frequency. Among the structural proteins, spike glycoprotein and nucleocapsid phosphoprotein accumulated a larger number of mutations whereas envelope and membrane proteins are mostly conserved. Spike protein and RNA-dependent RNA polymerase variants, D614G and P323L in combination became dominant world-wide. Divergent genetic variants created serious challenge towards the development of therapeutics and vaccines. This review will consolidate mutations in different SARS-CoV-2 proteins and their implications on viral fitness. Twit Text FOAVip SARS-CoV-2 mutations: the biological trackway towards viral fitness ????Epidemiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33928885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33928885 #FOAvip English Wikipedia <ref>{{Cite pmid|33928885}}</ref> SARS-CoV-2 mutations: the biological trackway towards viral fitness #MMPMID33928885 Majumdar P; Niyogi S Epidemiol Infect 2021[Apr]; 149 (ä): e110 PMID33928885show ga The outbreak of pneumonia-like respiratory disorder at China and its rapid transmission world-wide resulted in public health emergency, which brought lineage B betacoronaviridae SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) into spotlight. The fairly high mutation rate, frequent recombination and interspecies transmission in betacoronaviridae are largely responsible for their temporal changes in infectivity and virulence. Investigation of global SARS-CoV-2 genotypes revealed considerable mutations in structural, non-structural, accessory proteins as well as untranslated regions. Among the various types of mutations, single-nucleotide substitutions are the predominant ones. In addition, insertion, deletion and frame-shift mutations are also reported, albeit at a lower frequency. Among the structural proteins, spike glycoprotein and nucleocapsid phosphoprotein accumulated a larger number of mutations whereas envelope and membrane proteins are mostly conserved. Spike protein and RNA-dependent RNA polymerase variants, D614G and P323L in combination became dominant world-wide. Divergent genetic variants created serious challenge towards the development of therapeutics and vaccines. This review will consolidate mutations in different SARS-CoV-2 proteins and their implications on viral fitness. |*Mutation[MESH] |Animals[MESH] |COVID-19/*virology[MESH] |Coronavirus Nucleocapsid Proteins/genetics[MESH] |Genome, Viral/genetics/*physiology[MESH] |Humans[MESH] |Multigene Family[MESH] |Phosphoproteins/genetics[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH] |Viral Regulatory and Accessory Proteins/genetics[MESH]SARS-CoV-2 mutations: the biological trackway towards viral fitness (epmc).pdf DeepDyve Pubget Overpricing