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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Hematol+Oncol 2021 ; 14 (1): 72 Nephropedia Template TP
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SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism #MMPMID33926500
Shen S; Zhang J; Fang Y; Lu S; Wu J; Zheng X; Deng F
J Hematol Oncol 2021[Apr]; 14 (1): 72 PMID33926500show ga
Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction. The current study showed that SARS-CoV-2 interacts with both platelets and megakaryocytes despite the limited efficiency. Abundance of the conventional receptor ACE2 and alternative receptors or co-factors for SARS-CoV-2 entry was characterized in platelets from COVID-19 patients and healthy persons as well as human megakaryocytes based on laboratory tests or previously reported RNA-seq data. The results suggest that SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism and may regulate alternative receptor expression associated with COVID-19 coagulation dysfunction.