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10.3390/vaccines9040376 http://scihub22266oqcxt.onion/10.3390/vaccines9040376 33924340!8069830!33924340     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vaccines+(Basel) 2021 ; 9 (4): ä Nephropedia Template TP {{tp|p=33924340|t=2021. Expanding COVID-19 Vaccine Availability: Role for Combined Orthogonal Serology Testing (COST) |pdf=|usr=}}{{33924340}} gab.com Text Expanding COVID-19 Vaccine Availability: Role for Combined Orthogonal Serology Testing (COST) JO: Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33924340 #FOAvip BACKGROUND: The persisting Coronavirus disease 2019 (COVID-19) pandemic and limited vaccine supply has led to a shift in global health priorities to expand vaccine coverage. Relying on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) molecular testing alone cannot reveal the infection proportion, which could play a critical role in vaccination prioritization. We evaluated the utility of a combination orthogonal serological testing (COST) algorithm alongside RT-PCR to quantify prevalence with the aim of identifying candidate patient clusters to receive single and/or delayed vaccination. METHODS: We utilized 108,505 patients with suspected COVID-19 in a retrospective analysis of SARS-CoV-2 RT-PCR vs. IgG-nucleocapsid (IgG(NC)) antibody testing coverage in routine practice for the estimation of prevalence. Prospectively, an independent cohort of 21,388 subjects was simultaneously tested by SARS-CoV-2 RT-PCR and IgG(NC) to determine the prevalence. We used 614 prospective study subjects to assess the utility of COST (IgG(NC), IgM-spike (IgM(SP)), and IgG-spike (IgG(SP))) in establishing the infection proportion to identify a single-dose vaccination cohort. RESULTS: Retrospectively, we observed a 6.3% (6871/108,505) positivity for SARS-CoV-2 RT-PCR, and only 2.3% (2533/108,505) of cases had paired IgG(NC) serology performed. Prospectively, IgG(NC) serology identified twice the number of COVID-positive cases in relation to RT-PCR alone. COST further increased the number of detected positive cases: IgG(NC)+ or IgM(SP)+ (18.0%); IgG(NC)+ or IgG(SP)+ (23.5%); IgM(SP)+ or IgG(SP)+ (23.8%); and IgG(NC)+ or IgM(SP)+ or IgG(SP)+ (141/584 = 24.1%). CONCLUSION: COST may be an effective tool for the evaluation of infection proportion and thus could define a cohort for a single dose and/or delayed vaccination. Twit Text FOAVip Expanding COVID-19 Vaccine Availability: Role for Combined Orthogonal Serology Testing (COST) ????Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33924340 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33924340 #FOAvip English Wikipedia <ref>{{Cite pmid|33924340}}</ref> Expanding COVID-19 Vaccine Availability: Role for Combined Orthogonal Serology Testing (COST) #MMPMID33924340 Narasimhan M; Mahimainathan L; Araj E; Clark AE; Wilkinson K; Yekkaluri S; Tiro J; Lee FM; Balani J; Sarode R; Singal AG; Muthukumar A Vaccines (Basel) 2021[Apr]; 9 (4): ä PMID33924340show ga BACKGROUND: The persisting Coronavirus disease 2019 (COVID-19) pandemic and limited vaccine supply has led to a shift in global health priorities to expand vaccine coverage. Relying on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) molecular testing alone cannot reveal the infection proportion, which could play a critical role in vaccination prioritization. We evaluated the utility of a combination orthogonal serological testing (COST) algorithm alongside RT-PCR to quantify prevalence with the aim of identifying candidate patient clusters to receive single and/or delayed vaccination. METHODS: We utilized 108,505 patients with suspected COVID-19 in a retrospective analysis of SARS-CoV-2 RT-PCR vs. IgG-nucleocapsid (IgG(NC)) antibody testing coverage in routine practice for the estimation of prevalence. Prospectively, an independent cohort of 21,388 subjects was simultaneously tested by SARS-CoV-2 RT-PCR and IgG(NC) to determine the prevalence. We used 614 prospective study subjects to assess the utility of COST (IgG(NC), IgM-spike (IgM(SP)), and IgG-spike (IgG(SP))) in establishing the infection proportion to identify a single-dose vaccination cohort. RESULTS: Retrospectively, we observed a 6.3% (6871/108,505) positivity for SARS-CoV-2 RT-PCR, and only 2.3% (2533/108,505) of cases had paired IgG(NC) serology performed. Prospectively, IgG(NC) serology identified twice the number of COVID-positive cases in relation to RT-PCR alone. COST further increased the number of detected positive cases: IgG(NC)+ or IgM(SP)+ (18.0%); IgG(NC)+ or IgG(SP)+ (23.5%); IgM(SP)+ or IgG(SP)+ (23.8%); and IgG(NC)+ or IgM(SP)+ or IgG(SP)+ (141/584 = 24.1%). CONCLUSION: COST may be an effective tool for the evaluation of infection proportion and thus could define a cohort for a single dose and/or delayed vaccination. äExpanding COVID-19 Vaccine Availability: Role for Combined Orthogonal (epmc).pdf DeepDyve Pubget Overpricing