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10.3390/genes12050635 http://scihub22266oqcxt.onion/10.3390/genes12050635 33923155!8145325!33923155     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33923155&cmd=llinks): Failed to open stream: HTTP request failed! 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Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches |pdf=|usr=}}{{33923155}} gab.com Text Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33923155 #FOAvip Single-cell RNA sequencing of the bronchoalveolar lavage fluid (BALF) samples from COVID-19 patients has enabled us to examine gene expression changes of human tissue in response to the SARS-CoV-2 virus infection. However, the underlying mechanisms of COVID-19 pathogenesis at single-cell resolution, its transcriptional drivers, and dynamics require further investigation. In this study, we applied machine learning algorithms to infer the trajectories of cellular changes and identify their transcriptional programs. Our study generated cellular trajectories that show the COVID-19 pathogenesis of healthy-to-moderate and healthy-to-severe on macrophages and T cells, and we observed more diverse trajectories in macrophages compared to T cells. Furthermore, our deep-learning algorithm DrivAER identified several pathways (e.g., xenobiotic pathway and complement pathway) and transcription factors (e.g., MITF and GATA3) that could be potential drivers of the transcriptomic changes for COVID-19 pathogenesis and the markers of the COVID-19 severity. Moreover, macrophages-related functions corresponded more to the disease severity compared to T cells-related functions. Our findings more proficiently dissected the transcriptomic changes leading to the severity of a COVID-19 infection. Twit Text FOAVip Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33923155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33923155 #FOAvip English Wikipedia <ref>{{Cite pmid|33923155}}</ref> Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches #MMPMID33923155 Jeong HH; Jia J; Dai Y; Simon LM; Zhao Z Genes (Basel) 2021[Apr]; 12 (5): ä PMID33923155show ga Single-cell RNA sequencing of the bronchoalveolar lavage fluid (BALF) samples from COVID-19 patients has enabled us to examine gene expression changes of human tissue in response to the SARS-CoV-2 virus infection. However, the underlying mechanisms of COVID-19 pathogenesis at single-cell resolution, its transcriptional drivers, and dynamics require further investigation. In this study, we applied machine learning algorithms to infer the trajectories of cellular changes and identify their transcriptional programs. Our study generated cellular trajectories that show the COVID-19 pathogenesis of healthy-to-moderate and healthy-to-severe on macrophages and T cells, and we observed more diverse trajectories in macrophages compared to T cells. Furthermore, our deep-learning algorithm DrivAER identified several pathways (e.g., xenobiotic pathway and complement pathway) and transcription factors (e.g., MITF and GATA3) that could be potential drivers of the transcriptomic changes for COVID-19 pathogenesis and the markers of the COVID-19 severity. Moreover, macrophages-related functions corresponded more to the disease severity compared to T cells-related functions. Our findings more proficiently dissected the transcriptomic changes leading to the severity of a COVID-19 infection. |*Macrophages/physiology/virology[MESH] |*T-Lymphocytes/physiology/virology[MESH] |Algorithms[MESH] |Bronchoalveolar Lavage Fluid/*virology[MESH] |COVID-19/*etiology/genetics/*pathology[MESH] |Computational Biology/methods[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Machine Learning[MESH] |Sequence Analysis, RNA/methods[MESH]Investigating Cellular Trajectories in the Severity of COVID-19 and Th(epmc).pdf DeepDyve Pubget Overpricing